ZMYND11 - zinc finger MYND-type containing 11 Gene

中文名称：含锌指 MYND 型 11

种属: Homo sapiens

同用名: BS69; BRAM1; MRD30

基因 ID: 10771 | 基因类型: protein coding

关于 ZMYND11

Cytogenetic location: 10p15.3 Genomic coordinates (GRCh38): 10:130,088-254,637 (from NCBI)

This gene has 26 transcripts (splice variants), 212 orthologues, 5 paralogues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 38.3), brain (RPKM 25.5) and 25 other tissues.

功能概要

由该基因编码的蛋白质首先通过其结合腺病毒 E1A 蛋白的能力得到鉴定。蛋白质定位于细胞核。它起转录抑制因子的作用，E1A 的表达会抑制这种抑制作用。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

ZMYND11 基因产物(36)

mRNA	Protein	Name
NM_001202464.3	NP_001189393.1	zinc finger MYND domain-containing protein 11 isoform c
NM_001202465.3	NP_001189394.1	zinc finger MYND domain-containing protein 11 isoform d
NM_001202466.3	NP_001189395.1	zinc finger MYND domain-containing protein 11 isoform e
NM_001202467.1	NP_001189396.1	zinc finger MYND domain-containing protein 11 isoform f
NM_001202468.1	NP_001189397.1	zinc finger MYND domain-containing protein 11 isoform g
NM_001330057.3	NP_001316986.1	zinc finger MYND domain-containing protein 11 isoform h
NM_001370097.3	NP_001357026.1	zinc finger MYND domain-containing protein 11 isoform a
NM_001370098.2	NP_001357027.1	zinc finger MYND domain-containing protein 11 isoform a
NM_001370099.2	NP_001357028.1	zinc finger MYND domain-containing protein 11 isoform a
NM_001370100.5	NP_001357029.1	zinc finger MYND domain-containing protein 11 isoform a
NM_001370101.2	NP_001357030.1	zinc finger MYND domain-containing protein 11 isoform a
NM_001370102.2	NP_001357031.1	zinc finger MYND domain-containing protein 11 isoform a
NM_001370103.2	NP_001357032.1	zinc finger MYND domain-containing protein 11 isoform c
NM_001370104.2	NP_001357033.1	zinc finger MYND domain-containing protein 11 isoform c
NM_001370105.2	NP_001357034.1	zinc finger MYND domain-containing protein 11 isoform c
NM_001370106.2	NP_001357035.1	zinc finger MYND domain-containing protein 11 isoform c
NM_001370107.2	NP_001357036.1	zinc finger MYND domain-containing protein 11 isoform c
NM_001370108.2	NP_001357037.1	zinc finger MYND domain-containing protein 11 isoform c
NM_001370109.2	NP_001357038.1	zinc finger MYND domain-containing protein 11 isoform c
NM_001370110.2	NP_001357039.1	zinc finger MYND domain-containing protein 11 isoform d
NM_001370111.2	NP_001357040.1	zinc finger MYND domain-containing protein 11 isoform e
NM_001370112.2	NP_001357041.1	zinc finger MYND domain-containing protein 11 isoform h
NM_001370113.2	NP_001357042.1	zinc finger MYND domain-containing protein 11 isoform i
NM_001370114.2	NP_001357043.1	zinc finger MYND domain-containing protein 11 isoform i
NM_001370115.2	NP_001357044.1	zinc finger MYND domain-containing protein 11 isoform j
NM_001370116.2	NP_001357045.1	zinc finger MYND domain-containing protein 11 isoform k
NM_001370117.2	NP_001357046.1	zinc finger MYND domain-containing protein 11 isoform l
NM_001370118.2	NP_001357047.1	zinc finger MYND domain-containing protein 11 isoform m
NM_001370119.2	NP_001357048.1	zinc finger MYND domain-containing protein 11 isoform n
NM_001370120.2	NP_001357049.1	zinc finger MYND domain-containing protein 11 isoform o
NM_001370121.2	NP_001357050.1	zinc finger MYND domain-containing protein 11 isoform p
NM_001370122.2	NP_001357051.1	zinc finger MYND domain-containing protein 11 isoform q
NM_001370123.2	NP_001357052.1	zinc finger MYND domain-containing protein 11 isoform r
NM_001370124.3	NP_001357053.1	zinc finger MYND domain-containing protein 11 isoform s
NM_006624.7	NP_006615.2	zinc finger MYND domain-containing protein 11 isoform a
NM_212479.4	NP_997644.2	zinc finger MYND domain-containing protein 11 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables double-stranded DNA binding	IDA IDA: 通过直接分析推断	24675531	GOA
enables methylated histone binding	IDA IDA: 通过直接分析推断	24675531	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10734313	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	24675531	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in defense response to virus	IDA IDA: 通过直接分析推断	26845565	GOA
involved in negative regulation of JNK cascade	IMP IMP: 通过突变表型推断	20732415	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	20732415	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: 通过突变表型推断	20732415	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	24675531	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZMYND11 蛋白结构

Bromodomain

PWWP

0
100
200
300
400
500
602 a.a.

蛋白主名

其他名称

zinc finger MYND domain-containing protein 11

adenovirus 5 E1A-binding protein

ZMYND11 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ZMYND11	Q15326	ZHX1	Homo sapiens	Q9UKY1	Phage Display	35044719
种属内	ZMYND11	Q15326	LTBR	Homo sapiens	P36941	Y2H	20732415
种属内	ZMYND11	Q15326	LTBR	Homo sapiens	P36941	Anti Tag CoIP	20732415
种属内	ZMYND11	Q15326	TRAF3	Homo sapiens	Q13114	Anti Tag CoIP	20138174
种属间	ZMYND11	Q15326	e1a_ade05	Human adenovirus C	P03255	Pull Down	11733528
种属间	ZMYND11	Q15326	e1a_ade05	Human adenovirus C	P03255	Anti Bait CoIP	11733528
种属间	ZMYND11	Q15326	LMP1	Epstein-Barr virus	P03230	Anti Tag CoIP	20138174
种属间	ZMYND11	Q15326	EBNA2	Epstein-Barr virus	P12978	Anti Bait CoIP	11733528
种属间	ZMYND11	Q15326	EBNA2	Epstein-Barr virus	P12978	Pull Down	11733528

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Intellectual Developmental Disorder, Autosomal Dominant 30, With Speech Delay And Behavioral Abnormalities

MRD30	Mental Retardation, Autosomal Dominant 30
Intellectual Developmental Disorder, Autosomal Dominant 30	Autosomal Dominant Non-Syndromic Intellectual Disability 30
Autosomal Dominant Intellectual Developmental Disorder 30	Autosomal Dominant Mental Retardation 30
Mental Retardation, Autosomal Dominant, Type 30

Autosomal Dominant Intellectual Disability 30

Intellectual Disability, Autosomal Dominant 30

Autosomal Dominant Non-Syndromic Intellectual Disability

Fibrodysplasia Ossificans Progressiva

Myositis Ossificans Progressiva	Progressive Myositis Ossificans
FOP	Progressive Ossifying Myositis
Myositis Ossificans	Stone Man Syndrome
Man Of Stone	Myositis Ossificans Progressive
Diffuse Progressive Ossifying Polymyositis	Fibrodysplasia Ossificans Congenita
Myositis Ossificans Progressiva, Site Unspecified	Münchmeyer Disease
Fop - [Fibrodysplasia Ossificans Progressiva]	Progressive Myositis Ossificans Calcification

Hypoparathyroidism-Deafness-Renal Disease Syndrome

Barakat Syndrome	Hypoparathyroidism, Deafness, Renal Disease Syndrome
Hdr Syndrome	Hypoparathyroidism, Sensorineural Deafness, And Renal Disease

Familial Cold Autoinflammatory Syndrome 3

Plaid	Familial Atypical Cold Urticaria
Facu	FCAS3
Antibody Deficiency And Immune Dysregulation, Plcg2-Associated	Plcg2-Associated Antibody Deficiency And Immune Dysregulation
Familial Cold Urticaria With Common Variable Immunodeficiency	Plcg2 Associated Antibody Deficiency And Immune Dysregulation
Antibody Deficiency And Immune Dysregulation Placg2-Associated	Autoinflammatory Syndrome, Cold, Familial, Type 3

Ptosis

Blepharoptosis	Drooping Eyelid
Droopy Eyelid	Ptosis Of Eyelid
Paralysis Of Levator Palpebrae Superioris

Nephronophthisis 3

NPHP3	Nph3
Adolescent Nephronophthisis	Nephronophthisis, Type 3

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16094	ZMYND11 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ZMYND11	MGD	MGI:1913755
Macaca mulatta	ZMYND11	VGNC	VGNC:79060
Bos taurus	ZMYND11	VGNC	VGNC:37202
Rattus norvegicus	ZMYND11	RGD	RGD:1303252
Canis familiaris	ZMYND11	VGNC	VGNC:48651

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