BLCAP - BLCAP apoptosis inducing factor Gene

中文名称：BLCAP 凋亡诱导因子

种属: Homo sapiens

同用名: BC10

关于 BLCAP

功能概要

该基因编码一种通过刺激细胞凋亡来减少细胞生长的蛋白质。可变剪接和替代启动子的使用导致编码相同蛋白质的多个转录变体。该基因印记在大脑中，每个亲本等位基因表达不同的转录变体。从上游启动子启动的转录变体优先从母系等位基因表达，而从散布的 NNAT 基因 (GeneID:4826) 下游启动的转录变体则从父系等位基因表达。该位点的转录本也可能进行 A 到 I 编辑，导致蛋白质 N 末端三个位置的氨基酸发生变化。[RefSeq 提供，2015 年 11 月]

This gene encodes a protein that reduces cell growth by stimulating Apoptosis. Alternative splicing and the use of alternative promoters result in multiple transcript variants encoding the same protein. This gene is imprinted in brain where different transcript variants are expressed from each parental allele. Transcript variants initiating from the upstream promoter are expressed preferentially from the maternal allele, while transcript variants initiating downstream of the interspersed NNAT gene (GeneID:4826) are expressed from the paternal allele. Transcripts at this locus may also undergo A to I editing, resulting in amino acid changes at three positions in the N-terminus of the protein. [provided by RefSeq, Nov 2015]