1. Gene
  2. PRSS21 - serine protease 21 Gene

PRSS21 - serine protease 21 Gene

中文名称:丝氨酸蛋白酶 21

种属: Homo sapiens

同用名: ESP1; ESP-1; TEST1; TESTISIN

基因 ID: 10942 | 基因类型: protein coding

关于 PRSS21

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,817,237-2,821,719 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 182 orthologues and 17 paralogues. Biased expression in testis (RPKM 26.0), bone marrow (RPKM 4.4) and 4 other tissues.

功能概要

该基因编码细胞表面锚定的丝氨酸蛋白酶,它是丝氨酸蛋白酶胰蛋白酶家族的成员。预测所编码的蛋白质对涉及赖氨酸或精氨酸的羧基的肽键具有活性。编码的蛋白质定位于减数分裂前睾丸生殖细胞的细胞质和质膜,并可能参与生殖细胞来源的睾丸肿瘤的进展。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供,2012 年 7 月]

This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

PRSS21 基因产物(4)

mRNA Protein Name
NM_001270452.2 NP_001257381.1 testisin isoform 4 preproprotein
NM_006799.4 NP_006790.1 testisin isoform 1 preproprotein
NM_144956.3 NP_659205.1 testisin isoform 2 preproprotein
NM_144957.3 NP_659206.1 testisin isoform 3 preproprotein

PRSS21 蛋白结构

Trypsin

Trypsin: Trypsin (42 - 281)

  • 0
  • 100
  • 200
  • 314 a.a.
蛋白主名 其他名称

testisin

eosinophil serine protease 1

关联疾病

疾病名称 别名
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis

Inflammatory Bowel Disease 12

IBD12

Cataract 37

CTRCT37

Cca5

Cataract, Congenital, Cerulean Type, 5

Cataract 37, Autosomal Dominant

Congenital Cataract Cerulean Type 5

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PRSS21 RGD RGD:727870
Mus musculus PRSS21 MGD MGI:1916698
Macaca mulatta PRSS21 VGNC VGNC:76432