2. Gene
  3. TLK2 - tousled like kinase 2 Gene

TLK2 - tousled like kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：凌乱样激酶 2

种属: Homo sapiens

同用名: HsHPK; MRD57; PKU-ALPHA

基因 ID: 11011 | 基因类型: protein coding

关于 TLK2

Cytogenetic location: 17q23.2 Genomic coordinates (GRCh38): 17:62,470,914-62,615,481 (from NCBI)

This gene has 32 transcripts (splice variants), 269 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 14.1), bone marrow (RPKM 5.4) and 25 other tissues.

功能概要

该基因编码的核丝氨酸/苏氨酸激酶最初是在拟南芥中发现的。编码的蛋白质被认为通过调节组蛋白 H3/H4 伴侣的水平在细胞周期 S 期染色质组装的调节中起作用。这种蛋白质与辐射引起的 DNA 损伤的双链断裂修复有关。该基因的假基因存在于 10 号和 17 号染色体上。交替剪接导致多个转录变体。[RefSeq 提供，2013 年 9 月]

This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

TLK2 基因产物(10)

mRNA Protein Name
NM_001284333.3 NP_001271262.1 serine/threonine-protein kinase tousled-like 2 isoform C
NM_001284363.1 NP_001271292.1 serine/threonine-protein kinase tousled-like 2 isoform B
NM_001330418.3 NP_001317347.1 serine/threonine-protein kinase tousled-like 2 isoform D
NM_001375269.1 NP_001362198.1 serine/threonine-protein kinase tousled-like 2 isoform E
NM_001375270.1 NP_001362199.1 serine/threonine-protein kinase tousled-like 2 isoform A
NM_001375271.1 NP_001362200.1 serine/threonine-protein kinase tousled-like 2 isoform A
NM_001375272.1 NP_001362201.1 serine/threonine-protein kinase tousled-like 2 isoform B
NM_001375273.1 NP_001362202.1 serine/threonine-protein kinase tousled-like 2 isoform D
NM_001411074.1 NP_001398003.1 serine/threonine-protein kinase tousled-like 2 isoform F
NM_006852.6 NP_006843.2 serine/threonine-protein kinase tousled-like 2 isoform A

TLK2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (464 - 741)

  • 0
  • 200
  • 400
  • 600
  • 772 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase tousled-like 2

重组 TLK2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76106 TLK2 Protein, Human (sf9) Q86UE8 (L397-N772) ≥95%
HY-P76107 TLK2 Protein, Human (sf9, His-GST) Q86UE8 (L397-N772) ≥95%

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, Autosomal Dominant 57

Mental Retardation, Autosomal Dominant 57

MRD57
Pica Disease

Pica
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14571 TLK2 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TLK2 RGD RGD:1310907
Mus musculus TLK2 MGD MGI:1346023
Felis catus TLK2 VGNC VGNC:66212
Bos taurus TLK2 VGNC VGNC:35894
Macaca mulatta TLK2 VGNC VGNC:78368
Canis familiaris TLK2 VGNC VGNC:47399
Others TLK2 NCBI
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