MID2 - midline 2 Gene

中文名称：中线 2

种属: Homo sapiens

同用名: FXY2; RNF60; TRIM1; MRX101; XLID101

基因 ID: 11043 | 基因类型: protein coding

关于 MID2

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:107,825,735-107,931,637 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues, 80 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 3.8), fat (RPKM 3.4) and 24 other tissues.

功能概要

由该基因编码的蛋白质是三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2，以及一个卷曲螺旋区域。该蛋白质定位于细胞质中的微管结构。该基因的交替剪接导致编码不同亚型的两个转录变体。[RefSeq 提供，2009 年 2 月]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]

MID2 基因产物(4)

mRNA	Protein	Name
NM_001382751.1	NP_001369680.1	probable E3 ubiquitin-protein ligase MID2 isoform 3
NM_001382752.1	NP_001369681.1	probable E3 ubiquitin-protein ligase MID2 isoform 4
NM_012216.4	NP_036348.2	probable E3 ubiquitin-protein ligase MID2 isoform 1
NM_052817.3	NP_438112.2	probable E3 ubiquitin-protein ligase MID2 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme binding	IPI IPI: 通过物理相互作用推断	11806752	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables microtubule binding	IMP IMP: 通过突变表型推断	11806752	GOA
enables phosphoprotein binding	IPI IPI: 通过物理相互作用推断	11806752	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	11806752	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	23077300	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in innate immune response	IDA IDA: 通过直接分析推断	18248090	GOA
involved in negative regulation of viral entry into host cell	IDA IDA: 通过直接分析推断	18248090	GOA
involved in negative regulation of viral transcription	IDA IDA: 通过直接分析推断	18248090	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	23077300	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	23077300	GOA
involved in positive regulation of autophagy	IMP IMP: 通过突变表型推断	26347139	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	23077300	GOA
involved in protein localization to microtubule	IMP IMP: 通过突变表型推断	11806752	GOA
involved in suppression of viral release by host	IDA IDA: 通过直接分析推断	18248090	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
colocalizes with microtubule	IDA IDA: 通过直接分析推断	10400986	GOA
located in microtubule	IDA IDA: 通过直接分析推断	11806752	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MID2 蛋白结构

zf-C3HC4_3

zf-B_box

SPRY

0
200
400
600
735 a.a.

蛋白主名

其他名称

probable E3 ubiquitin-protein ligase MID2

RING finger protein 60

关联疾病

疾病名称

别名

Intellectual Developmental Disorder, X-Linked 101

XLID101	Mental Retardation, X-Linked 101
Mrx101	Mental Retardation, X-Linked, Type 101

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Opitz Gbbb Syndrome

Opitz G/Bbb Syndrome	Opitz Syndrome
Hypertelorism-Hypospadias Syndrome	Hypertelorism With Esophageal Abnormality And Hypospadias
Opitz-Frias Syndrome	Os
Osx	Telecanthus-Hypospadias Syndrome
Opitz Gbbb Syndrome Type I	Opitz Bbbg Syndrome
Hypospadias-Dysphagia Syndrome	Opitz Bbb/G Syndrome
GBBB	Opitz Gbbb Syndrome, X-Linked
Opitz Syndrome, X-Linked	Opitz Gbbb Syndrome, Type I, Formerly
Gbbb1, Formerly	Opitz-G Syndrome, Type I, Formerly
Ogs1, Formerly	Opitz Bbbg Syndrome, Type I, Formerly
Bbbg1, Formerly	Bbb Syndrome
G Syndrome	Gbbb Syndrome
Hypertelorism Hypospadias Syndrome	Hypospadias-Dysphagia, Syndrome
Opitz-G Syndrome, Type 2	Telecanthus With Associated Abnormalities
Hypertelorism With Esophageal Abnormalities And Hypospadias	Hypertelorism-Hypospadias Sydrome
Opitz Bbb Syndrome	Opitz G Syndrome
Hypertelorism-Oesophageal Abnormality-Hypospadias Syndrome	Opitz Gbbb Syndrome 1
GBBB1	Bbbg1
Gggb1	Opitz Bbbg Syndrome Type I
Opitz Gbbb Syndrome X-Linked	Opitz-G Syndrome Type I
Opitz Syndrome X-Linked	Opitz G Syndrome, Type I
Opitz Bbbg Syndrome, Type I

Hypospadias

Hypospadias Familial

Familial Hypospadias

Non-Syndromic X-Linked Intellectual Disability 63

Acsl4-Related Intellectual Disability	Mrx63
Mrx68	X-Linked Mental Retardation 68

Non-Syndromic X-Linked Intellectual Disability 101

Mrx101

X-Linked Mental Retardation 101

Myringitis Bullosa Hemorrhagica

Bullous Myringitis

Non-Syndromic X-Linked Intellectual Disability 30

Mrx30	Mrx47
X-Linked Mental Retardation 30/47	X-Linked Mental Retardation 47
Mental Retardation, X-Linked, Type 30/47

Tetanus Neonatorum

Neonatal Tetanus	NNT
Trismus Neonatorum	Newborn Trismus

Opitz-Kaveggia Syndrome

Fg Syndrome	Fgs1
Fgs	Keller Syndrome
OKS	Fg Syndrome 1
Fg Syndrome Type 1	Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum
Intellectual Disability, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum	Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum

Urinary Schistosomiasis

Schistosoma Haematobium Infection	Schistosoma Hematobium Infection
Schistosomiasis Due To Schistosoma Haematobium	Bladder Schistosomiasis
Cystitis With Bilharziasis	Schistosoma Haematobium
Schistosoma Hematobium Infectious Disease	Schistosomiasis Of Bladder
Vesical Schistosomiasis	Schistosomiasis Urinary
Schistosomiasis Haematobia	Genitourinary Bilharziasis
Genitourinary Tract Schistosomiasis	Schistosomiasis Due To Schistosoma Haematobium [Urinary Schistosomiasis]
Haematochyluria In Schistosomiasis	Infection Due To Schistosoma Matthei

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-W854844A	(E)-JP-2-196 TFA	Ligand	/	否
HY-RS08436	MID2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	MID2	VGNC	VGNC:43224
Mus musculus	MID2	MGD	MGI:1344333
Macaca mulatta	MID2	VGNC	VGNC:74722
Rattus norvegicus	MID2	RGD	RGD:1565674
Bos taurus	MID2	VGNC	VGNC:106822
Felis catus	MID2	VGNC	VGNC:68256

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MID2 - midline 2 Gene

关于 MID2

功能概要

MID2 基因产物(4)

MID2 蛋白结构

关联疾病

直系同源

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MID2 - midline 2 Gene

关于 MID2

功能概要

MID2 基因产物(4)

MID2 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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C

F

G

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J

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Q

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