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  2. UBE2C - ubiquitin conjugating enzyme E2 C Gene

UBE2C - ubiquitin conjugating enzyme E2 C Gene

中文名称:泛素结合酶 E2 C

种属: Homo sapiens

同用名: UBCH10; dJ447F3.2

基因 ID: 11065 | 基因类型: protein coding

关于 UBE2C

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,812,644-45,816,952 (from NCBI)

This gene has 8 transcripts (splice variants), 220 orthologues and 24 paralogues. Biased expression in bone marrow (RPKM 14.3), lymph node (RPKM 11.0) and 13 other tissues.

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶:泛素激活酶、泛素结合酶和泛素蛋白连接酶。该基因编码 E2 泛素结合酶家族的成员。编码的蛋白质是破坏有丝分裂细胞周期蛋白和细胞周期进程所必需的,并且可能参与癌症进程。已发现该基因编码不同异构体的多个转录变体。该基因的假基因已在 4、14、15、18 和 19 号染色体上定义。[RefSeq 提供,2013 年 8 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in Cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]

UBE2C 基因产物(6)

mRNA Protein Name
NM_001281741.2 NP_001268670.1 ubiquitin-conjugating enzyme E2 C isoform 6
NM_001281742.2 NP_001268671.1 ubiquitin-conjugating enzyme E2 C isoform 7
NM_007019.4 NP_008950.1 ubiquitin-conjugating enzyme E2 C isoform 1
NM_181799.3 NP_861515.1 ubiquitin-conjugating enzyme E2 C isoform 2
NM_181800.3 NP_861516.1 ubiquitin-conjugating enzyme E2 C isoform 3
NM_181801.4 NP_861517.1 ubiquitin-conjugating enzyme E2 C isoform 4

UBE2C 蛋白结构

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (34 - 167)

  • 0
  • 100
  • 179 a.a.
蛋白主名 其他名称

ubiquitin-conjugating enzyme E2 C

(E3-independent) E2 ubiquitin-conjugating enzyme C

重组 UBE2C 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71016 UBE2C Protein, Human (His) O00762 (M1-P179) ≥95%

关联疾病

疾病名称 别名
Complement Component 7 Deficiency

C7 Deficiency

C7D

Methotrexate-Associated Lymphoproliferation
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus UBE2C VGNC VGNC:99692
Canis familiaris UBE2C VGNC VGNC:48049
Bos taurus UBE2C VGNC VGNC:36578
Mus musculus UBE2C MGD MGI:1915862
Rattus norvegicus UBE2C RGD RGD:1305382
Others UBE2C NCBI