UBE2C - ubiquitin conjugating enzyme E2 C Gene

中文名称：泛素结合酶 E2 C

种属: Homo sapiens

同用名: UBCH10; dJ447F3.2

关于 UBE2C

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶、泛素结合酶和泛素蛋白连接酶。该基因编码 E2 泛素结合酶家族的成员。编码的蛋白质是破坏有丝分裂细胞周期蛋白和细胞周期进程所必需的，并且可能参与癌症进程。已发现该基因编码不同异构体的多个转录变体。该基因的假基因已在 4、14、15、18 和 19 号染色体上定义。[RefSeq 提供，2013 年 8 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, ubiquitin-conjugating Enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in Cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]