2. Gene
  3. Gabra5 - gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 Gene

Gabra5 - gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: A230018I05Rik

基因 ID: 110886 | 基因类型: protein coding

关于 Gabra5

功能概要

Predicted to enable GABA Receptor binding activity and extracellular ligand-gated ion channel activity. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and Chloride Channel activity. Involved in several processes, including inner ear development; innervation; and sensory perception of sound. Acts upstream of or within associative learning and behavioral fear response. Located in cell body and dendrite. Is expressed in brain. Human ortholog(s) of this gene implicated in bipolar disorder; developmental and epileptic encephalopathy 79; and mental depression. Orthologous to human GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5). [provided by Alliance of Genome Resources, Apr 2022]

Gabra5 基因产物(3)

mRNA Protein Name
NM_001362161.1 NP_001349090.1 gamma-aminobutyric acid receptor subunit alpha-5 precursor
NM_001362162.1 NP_001349091.1 gamma-aminobutyric acid receptor subunit alpha-5 precursor
NM_176942.4 NP_795916.1 gamma-aminobutyric acid receptor subunit alpha-5 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GABA-A receptor activity IMP
IMP: 通过突变表型推断
14993607 MGI
enables GABA-gated chloride ion channel activity IMP
IMP: 通过突变表型推断
14993607 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16467845 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within associative learning IMP
IMP: 通过突变表型推断
12084936 MGI
acts upstream of or within behavioral fear response IMP
IMP: 通过突变表型推断
12084936 MGI
involved in cochlea development IMP
IMP: 通过突变表型推断
17021187 MGI
involved in inner ear receptor cell development IMP
IMP: 通过突变表型推断
17021187 MGI
involved in innervation IMP
IMP: 通过突变表型推断
17021187 MGI
involved in neuron development IMP
IMP: 通过突变表型推断
17021187 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell body IDA
IDA: 通过直接分析推断
9682826 MGI
located in dendrite IDA
IDA: 通过直接分析推断
9682826 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

gamma-aminobutyric acid receptor subunit alpha-5

GABA(A) receptor subunit alpha-5

ligand-gated ion channel subunit

Gabra5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Gabra5 Q8BHJ7 Rdx Rattus norvegicus Q5WQV5
Pull Down
16467845
种属间
Gabra5 Q8BHJ7 Rdx Rattus norvegicus Q5WQV5
Y2H
16467845
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05213 GABRA5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21856 Gabra5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28373 Gabra5 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gabra5 NCBI NCBI:2558
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