2. Gene
  3. LZTS1 - leucine zipper tumor suppressor 1 Gene

LZTS1 - leucine zipper tumor suppressor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：亮氨酸拉链抑癌基因 1

种属: Homo sapiens

同用名: F37; FEZ1

基因 ID: 11178 | 基因类型: protein coding

关于 LZTS1

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:20,246,165-20,303,963 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in testis (RPKM 4.1), brain (RPKM 3.1) and 19 other tissues.

功能概要

该基因编码一种在正常组织中普遍表达的肿瘤抑制蛋白。在葡萄膜黑色素瘤中，该蛋白的表达在快速转移和转移性肿瘤细胞中沉默，但在缓慢转移或非转移性肿瘤细胞中表达正常。这种蛋白质可能通过与 CDK1/cyclinB1 复合物相互作用而在细胞周期控制中发挥作用。该基因位于染色体区域 8p22。 8p 臂杂合性缺失 (LOH) 是许多类型癌症的共同特征。[RefSeq 提供，2009 年 11 月]

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the CDK1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of Cancer. [provided by RefSeq, Nov 2009]

LZTS1 基因产物(2)

mRNA Protein Name
NM_001362884.2 NP_001349813.1 leucine zipper putative tumor suppressor 1
NM_021020.5 NP_066300.1 leucine zipper putative tumor suppressor 1

LZTS1 蛋白结构

Fez1

Fez1: Fez1 (380 - 566)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 596 a.a.
蛋白主名 其他名称

leucine zipper putative tumor suppressor 1

F37/Esophageal cancer-related gene-coding leucine-zipper motif

关联疾病

疾病名称 别名
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Ehlers-Danlos Syndrome

Eds

Cutis Hyperelastica

Elastic Skin

Ehlers-Danlos Syndromes

Ed Syndrome

Ehlers Danlos Syndrome

Ehlers Danlos Disease

Eds - [Ehlers-Danlos Syndrome]
Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder
Hypermobility Syndrome

Benign Joint Hypermobility
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07934 LZTS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LZTS1 RGD RGD:708565
Bos taurus LZTS1 VGNC VGNC:31121
Mus musculus LZTS1 MGD MGI:2684762
Macaca mulatta LZTS1 VGNC VGNC:74283
Canis familiaris LZTS1 VGNC VGNC:42905
Felis catus LZTS1 VGNC VGNC:63352
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