2. Gene
  3. Flt4 - Fms related receptor tyrosine kinase 4 Gene

Flt4 - Fms related receptor tyrosine kinase 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：fms 相关 受体酪氨酸激酶 4

种属: Rattus norvegicus

同用名: Vegfr3

基因 ID: 114110 | 基因类型: protein coding

关于 Flt4

Primary_assembly 10: 33,913,608-33,954,770 forward strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 196 orthologues, 54 paralogues and is associated with 14 phenotypes. Biased expression in Adrenal (RPKM 182.8), Lung (RPKM 61.9) and 7 other tissues.

功能概要

该基因编码的蛋白可启动生长因子结合活性和血管内皮生长因子激活受体活性。参与正向调节细胞生长和血管内皮生长因子受体信号通路。预测位于胞质溶胶中；核质；和质膜。预计是受体复合体的一部分。预计是质膜的组成部分。该基因的人类直系同源物与遗传性淋巴水肿 IA 有关。与人类 FLT4（fms 相关受体酪氨酸激酶 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in positive regulation of cell growth and vascular endothelial growth factor receptor signaling pathway. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Flt4 基因产物(1)

mRNA Protein Name
NM_053652.2 NP_446104.2 vascular endothelial growth factor receptor 3 precursor

Flt4 蛋白结构

Ig_2

Ig_2: pfam13895 (136 - 219)

IgI_VEGFR

IgI_VEGFR: cd05862 (229 - 328)

IgI_VEGFR

IgI_VEGFR: cd05862 (229 - 233)

IgI_VEGFR

IgI_VEGFR: cd05862 (239 - 243)

IgI_VEGFR

IgI_VEGFR: cd05862 (245 - 254)

IgI_VEGFR

IgI_VEGFR: cd05862 (261 - 266)

IgI_VEGFR

IgI_VEGFR: cd05862 (269 - 271)

IgI_VEGFR

IgI_VEGFR: cd05862 (275 - 283)

IgI_VEGFR

IgI_VEGFR: cd05862 (288 - 296)

IgI_VEGFR

IgI_VEGFR: cd05862 (306 - 312)

IgI_VEGFR

IgI_VEGFR: cd05862 (317 - 323)

Ig

Ig: cl11960 (330 - 417)

Ig

Ig: cd00096 (351 - 355)

Ig

Ig: cd00096 (364 - 368)

Ig

Ig: cd00096 (381 - 385)

Ig

Ig: cd00096 (395 - 400)

Ig

Ig: cd00096 (410 - 413)

IG_like

IG_like: smart00410 (569 - 662)

Ig

Ig: cd00096 (573 - 577)

Ig

Ig: cd00096 (586 - 590)

Ig

Ig: cd00096 (635 - 639)

Ig

Ig: cd00096 (649 - 654)

Ig

Ig: cl11960 (677 - 764)

Ig

Ig: cd00096 (694 - 698)

Ig

Ig: cd00096 (707 - 711)

Ig

Ig: cd00096 (730 - 734)

Ig

Ig: cd00096 (744 - 749)

VEGFR-2_TMD

VEGFR-2_TMD: pfam17988 (769 - 803)

PKc_like

PKc_like: cl21453 (836 - 1174)

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  • 1363 a.a.
蛋白主名 其他名称

vascular endothelial growth factor receptor 3

FLT-4

FMS-like tyrosine kinase 4

VEGFR-3

fms-related tyrosine kinase 4

tyrosine-protein kinase receptor FLT4

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10260 Vandetanib 99.95% 是
HY-10260B Vandetanib hydrochloride / 否
HY-10260A Vandetanib trifluoroacetate / 否
Clinical Phase
生物活性分子 (7)
目录号 产品名 作用方式
纯度 Phase
HY-10205 Cediranib 99.58% Phase 3
HY-100019 Rogaratinib Inhibitor 99.86% Phase 3
HY-13314 Tesevatinib Inhibitor 99.21% Phase 3
HY-13049 Cediranib maleate 99.95% Phase 3
HY-13034 Gandotinib Inhibitor 99.82% Phase 2
HY-10987A ENMD-2076 99.12% Phase 2
HY-10987 ENMD-2076 Tartrate 99.42% Phase 2
Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-116624 MAZ51 99.96% 否
HY-145293 TNIK-IN-3 Inhibitor 99.88% 否
HY-119933 RIPK1-IN-7 Inhibitor 98.67% 否
HY-15813 FIIN-1 Inhibitor 99.11% 否
HY-10260S Vandetanib-d6 / 否
HY-10260S1 Vandetanib-d4 / 否
HY-110272 Vatalanib succinate Inhibitor / 否
HY-155178 Antiproliferative agent-34 Inhibitor / 否
HY-RS04994 FLT4 Human Pre-designed siRNA Set A / 否
HY-RS04995 Flt4 Mouse Pre-designed siRNA Set A / 否
HY-RS04996 Flt4 Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Flt4 NCBI NCBI:2324
Mus musculus Flt4 NCBI NCBI:14257
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