2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Antiproliferative agent-34

Antiproliferative agent-34 (Compound A14) 是一种多靶点激酶抑制剂，对 EGFR L858R/T790M 和 EGFR WT 的 IC50 分别为 177 nM 和 1567 nM。Antiproliferative agent-34 还抑制 JAK2、ROS1、FLT3、FLT4、PDGFRα，IC50 为 30.93、106.90、108.00、226.60、42.53 nM。常氧条件下 Antiproliferative agent-34 抑制 H1975 和 HCC827 细胞增殖 的 IC50 值低于 40 nM，在缺氧条件下其抗增殖效力提高 4-6 倍 (IC50 值 < 10 nM)。

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Antiproliferative agent-34 Chemical Structure

Antiproliferative agent-34 Chemical Structure

CAS No. : 2910858-34-1

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Antiproliferative agent-34 相关抗体

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  • 生物活性

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生物活性

Antiproliferative agent-34 (Compound A14) is a multi-target kinase inhibitor, with an IC50 of 177 nM and 1567 nM for EGFR L858R/T790M and EGFR WT. Antiproliferative agent-34 also inhibits JAK2, ROS1, FLT3, FLT4, PDGFRα with IC50 of 30.93, 106.90, 108.00, 226.60, 42.53 nM. Antiproliferative agent-34 inhibits H1975 and HCC827 cells proliferation with IC50 values below 40 nM under normoxic condition, and the anti-proliferation potency achieves 4–6-fold improvement (IC50 values < 10 nM) under hypoxic condition[1].

IC50 & Target

177, 30.93, 106.90, 108.00, 226.60, 42.53 nM for EGFR L858R/T790M, JAK2, ROS1, FLT3, FLT4, PDGFRα respectively[1]
分子量

529.55

Formula

C27H27N7O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antiproliferative agent-34 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-342910858-34-1Antiproliferative agent34Antiproliferative agent 34EGFREpidermal growth factor receptorErbB-1HER1NSCLCH1975HCC827normoxichypoxicanti-proliferationInhibitorinhibitorinhibit

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