2. Gene
  3. Dnm1l - dynamin 1-like Gene

Dnm1l - dynamin 1-like Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: DLP1; Drp1; Dnml1

基因 ID: 114114 | 基因类型: protein coding

关于 Dnm1l

功能概要

Enables BH2 domain binding activity; clathrin binding activity; and identical protein binding activity. Involved in several processes, including mitochondrion organization; positive regulation of cellular component organization; and synaptic vesicle recycling. Located in several cellular components, including Golgi membrane; perinuclear region of cytoplasm; and peroxisome. Is active in presynaptic endocytic zone membrane and synaptic vesicle membrane. Colocalizes with clathrin-coated pit and mitochondrial membrane. Biomarker of chronic kidney disease; dental fluorosis; pulmonary fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Orthologous to human DNM1L (Dynamin 1 like). [provided by Alliance of Genome Resources, Apr 2022]

Dnm1l 基因产物(1)

mRNA Protein Name
NM_053655.3 NP_446107.2 dynamin-1-like protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables BH2 domain binding IPI
IPI: 通过物理相互作用推断
23792689 RGD
enables clathrin binding IPI
IPI: 通过物理相互作用推断
23792689 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
23658809 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
18250306 RGD
enables protein serine/threonine kinase binding IPI
IPI: 通过物理相互作用推断
20802490 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
23792689 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
23658809 RGD
involved in cellular response to lipid IEP
IEP: 通过表达模式推断
18006463 RGD
involved in intracellular distribution of mitochondria IMP
IMP: 通过突变表型推断
19605646 RGD
involved in mitochondrial fragmentation involved in apoptotic process IMP
IMP: 通过突变表型推断
17443673 RGD
involved in mitochondrion organization IMP
IMP: 通过突变表型推断
19605646 RGD
involved in negative regulation of mitochondrial fusion IMP
IMP: 通过突变表型推断
23792689 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: 通过突变表型推断
19605646 RGD
involved in positive regulation of mitochondrial fission IMP
IMP: 通过突变表型推断
17443673 RGD
involved in positive regulation of synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
23792689 RGD
involved in positive regulation of synaptic vesicle exocytosis IMP
IMP: 通过突变表型推断
23792689 RGD
involved in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
17443673 RGD
involved in response to flavonoid IEP
IEP: 通过表达模式推断
24637344 RGD
involved in response to hypobaric hypoxia IEP
IEP: 通过表达模式推断
24637344 RGD
involved in synaptic vesicle endocytosis IDA
IDA: 通过直接分析推断
23792689 RGD
involved in synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
23792689 RGD
involved in synaptic vesicle recycling via endosome IMP
IMP: 通过突变表型推断
23792689 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
9472031 RGD
NOT part of clathrin coat of trans-Golgi network vesicle IDA
IDA: 通过直接分析推断
9472031 RGD
located in clathrin-coated pit IDA
IDA: 通过直接分析推断
23792689 RGD
located in cytosol IDA
IDA: 通过直接分析推断
9472031 RGD
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
9472031 RGD
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
23792689 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
9472031 RGD
located in peroxisome IDA
IDA: 通过直接分析推断
12499366 RGD
NOT located in plasma membrane IDA
IDA: 通过直接分析推断
9472031 RGD
is active in presynaptic endocytic zone membrane IDA
IDA: 通过直接分析推断
23792689 RGD
located in secretory vesicle IDA
IDA: 通过直接分析推断
9472031 RGD
is active in synaptic vesicle membrane IDA
IDA: 通过直接分析推断
23792689 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

dynamin-1-like protein

C-terminal region

N-terminal region

dynamin-like protein 1

dynamin-related protein 1

Dnm1l 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Dnm1l O35303 Bcl2l1 Rattus norvegicus P53563-1
Anti Bait CoIP
23792689
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-N0484 Liensinine 99.97% Phase 2
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03904 DNM1L Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17698 Dnm1l Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24160 Dnm1l Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dnm1l NCBI NCBI:10059
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