2. Gene
  3. Macf1 - microtubule-actin crosslinking factor 1 Gene

Macf1 - microtubule-actin crosslinking factor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Acf7; MACF; Aclp7; ABP620; mKIAA0465; mKIAA0754; D830031N03Rik

基因 ID: 11426 | 基因类型: protein coding

关于 Macf1

功能概要

Enables actin binding activity and microtubule binding activity. Involved in several processes, including positive regulation of Wnt signaling pathway; regulation of focal adhesion assembly; and regulation of neuron projection arborization. Acts upstream of or within several processes, including Wnt signaling pathway; mesoderm formation; and posttranslational protein targeting to endoplasmic reticulum membrane. Located in cytoplasm; cytoskeleton; and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; limb segment; lung; and skeletal musculature. Human ortholog(s) of this gene implicated in lissencephaly 9 with complex brainstem malformation. Orthologous to human MACF1 (microtubule actin crosslinking factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Macf1 基因产物(4)

mRNA Protein Name
NM_001199136.2 NP_001186065.1 microtubule-actin cross-linking factor 1 isoform 1
NM_001199137.2 NP_001186066.1 microtubule-actin cross-linking factor 1 isoform 2
NM_001401293.2 NP_001388222.1 microtubule-actin cross-linking factor 1 isoform 3
NM_001401294.2 NP_001388223.1 microtubule-actin cross-linking factor 1 isoform 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP hydrolysis activity IDA
IDA: 通过直接分析推断
18854161 MGI
enables actin binding IDA
IDA: 通过直接分析推断
14636561 MGI
enables microtubule binding IDA
IDA: 通过直接分析推断
14636561 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16815997 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
16815997 MGI
acts upstream of or within Wnt signaling pathway IMP
IMP: 通过突变表型推断
16815997 MGI
acts upstream of or within cell migration IMP
IMP: 通过突变表型推断
14636561 MGI
acts upstream of or within establishment or maintenance of cell polarity IMP
IMP: 通过突变表型推断
14636561 MGI
acts upstream of or within mesoderm formation IMP
IMP: 通过突变表型推断
16815997 MGI
involved in positive regulation of Wnt signaling pathway IMP
IMP: 通过突变表型推断
16815997 MGI
acts upstream of or within post-translational protein targeting to endoplasmic reticulum membrane IMP
IMP: 通过突变表型推断
16815997 MGI
involved in regulation of epithelial cell migration IMP
IMP: 通过突变表型推断
18854161 MGI
involved in regulation of focal adhesion assembly IMP
IMP: 通过突变表型推断
18854161 MGI
involved in regulation of microtubule-based process IMP
IMP: 通过突变表型推断
21295697 MGI
involved in regulation of neuron projection arborization IMP
IMP: 通过突变表型推断
26526844 MGI
involved in wound healing IMP
IMP: 通过突变表型推断
18854161 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in actin cytoskeleton IDA
IDA: 通过直接分析推断
14636561 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
21295697 MGI
located in microtubule IDA
IDA: 通过直接分析推断
18854161 MGI
located in microtubule cytoskeleton IDA
IDA: 通过直接分析推断
14636561 MGI
located in postsynaptic density IDA
IDA: 通过直接分析推断
17114649 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

microtubule-actin cross-linking factor 1

actin cross-linking family 7

actin-crosslinking protein 7

trabeculin alpha

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07942 MACF1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22621 Macf1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29136 Macf1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Macf1 NCBI NCBI:23499
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