1. Signaling Pathways
  2. Stem Cell/Wnt
  3. Wnt

Wnt

The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell. Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three Wnt signaling pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the protein Dishevelled inside the cell. The canonical Wnt pathway leads to regulation of gene transcription, the noncanonical planar cell polarity pathway regulates the cytoskeleton that is responsible for the shape of the cell, and the noncanonical Wnt/calcium pathway regulates calcium inside the cell. The clinical importance of Wnt signaling pathway has been demonstrated by mutations that lead to a variety of diseases, including breast and prostate cancer, glioblastoma, type II diabetes.

Wnt 相关产品 (38):

Cat. No. Product Name Effect Purity
  • HY-15597
    Salinomycin Inhibitor >98.0%
    Salinomycin是具有强大的抗菌 (anti-bacterial) 活性的抗球虫药,和靶向人类癌症干细胞的新型抗癌剂。
  • HY-12238
    IWR-1 Inhibitor 99.83%
    IWR-1是端锚聚合酶抑制剂,抑制Wnt/β-catenin信号传导途径。
  • HY-101916
    Heparan Sulfate
    Heparan sulfate是一种复杂的线性多糖。它作为硫酸乙酰肝素蛋白聚糖的一部分出现,在细胞表面和细胞外基质中表达丰富。
  • HY-15659
    Wnt-C59 Inhibitor 99.56%
    Wnt-C59 (C59)是高效可口服的 PORCN 抑制剂,IC50 为 74 pM。
  • HY-A0293
    Pyrvinium pamoate Inhibitor >98.0%
    Pyrvinium pamoate是FDA批准的抗蠕虫药物,抑制 WNT 通路信号传导。
  • HY-100853
    IWP-O1 99.15%
    IWP-O1 是一个有效的Porcn 抑制剂,其在L-Wnt-STF 细胞中测得的 EC50 值为 80 pM。能够抑制HeLa细胞中Dvl2/3和LRP6的磷酸化。IWP-O1通过抑制Wnt蛋白的分泌发挥作用。
  • HY-122816
    HLY78 Activator >98.0%
    HLY78 是一种 Wnt/β-catenin 信号通路的激活剂,通过靶向通道中 Axin 的 DIX 域,强化 Axin-LRP6 交联来促进 Wnt 信号转导。
  • HY-114321
    Wnt/β-catenin agonist 1 Agonist
    Wnt/β-catenin agonist 1 (compound 3f) 是 Wnt/β-catenin 信号通路的一个激动剂,EC50 值为 0.27 μM。
  • HY-13912
    IWP-2 Inhibitor >98.0%
    IWP-2 抑制 Wnt 加工和分泌,IC50 为 27 nM。
  • HY-101085
    SKL2001 Agonist 98.08%
    SKL2001 是 Wnt/β-catenin 信号通路的激动剂,具有抗肿瘤活性。
  • HY-100830
    NCB-0846 Inhibitor 99.55%
    NCB-0846是具有口服活性的TNIK抑制剂,IC50值为21 nM。
  • HY-101090
    KYA1797K Inhibitor >98.0%
    KYA1797K是有效,选择性的 Wnt/β-catenin 抑制剂,IC50 值为0.75 µM。
  • HY-19987
    BML-284 Activator 99.98%
    BML-284是选择性和可渗透细胞的Wnt信号传导激活剂。
  • HY-15721
    FH535 Inhibitor 99.93%
    FH535 是 Wnt/β-cateninPPAR 的抑制剂,具有抗肿瘤活性。
  • HY-109049
    Adavivint Inhibitor 99.12%
    Adavivint 是一种有效的,选择性的典型的 Wnt 信号通路抑制剂,在 SW480 细胞中,用高通量 TCF/LEF 报告基因实验,测得 EC50 值为 19.5 nM。
  • HY-12681
    CCT251545 Inhibitor 99.34%
    CCT251545 是一种口服生物有效的 WNT 抑制剂, 在 7dF3 细胞中对 WNT 抑制作用的 IC50 值为 5 nM。
  • HY-18988
    ETC-159 Inhibitor 98.67%
    ETC-159是有效的,具有口服活性的 PORCN 抑制剂。抑制β-catenin报告基因活性的 IC50 值为2.9 nM。
  • HY-N0400
    Wogonin Inhibitor 99.98%
    Wogonin 是一种天然黄酮类物质,能够抑制 CDK8 and Wnt 的活性,具有抗炎、抗肿瘤等功效。
  • HY-16665
    iCRT 14 Inhibitor 98.90%
    iCRT 14 是一种 β-连环蛋白应答转录(CRT)抑制剂,能够抑制 Wnt 信号通路,IC50 值为 40.3 nM。
  • HY-101130
    PNU-74654 Inhibitor 99.83%
    PNU-74654是Wnt/β-catenin通路的的抑制剂,在NCI-H295 细胞中的IC50值为129.8 μM。
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