2. Gene
  3. Brdt - bromodomain, testis-specific Gene

Brdt - bromodomain, testis-specific Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：溴结构域，睾丸特异性

种属: Mus musculus

同用名: Brd6; Fsrg3; 7420412D09Rik

基因 ID: 114642 | 基因类型: protein coding

关于 Brdt

Chromosome 5: 107,479,025-107,534,924 forward strand.GRCm39:CM000998.3

This gene has 4 transcripts (splice variants), 148 orthologues, 11 paralogues and is associated with 18 phenotypes. Biased expression in testis adult (RPKM 12.3), cortex adult (RPKM 1.6) and 6 other tissues.

功能概要

该基因编码的蛋白质属于BET蛋白家族。 BET 蛋白有两个 N 端溴结构域和一个 C 端外端结构域（ET 结构域）。 BET 蛋白通过与乙酰化组蛋白结合来调节染色质重组。该基因被认为在精子发生的转录调节中发挥作用。虽然称为睾丸特异性溴结构域 (Brdt) 蛋白，但 RT-PCR 表明该基因在小鼠卵母细胞和睾丸中均有表达。可变剪接导致编码不同蛋白质的多个转录变体。 [RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the BET protein family. BET proteins have two N-terminal bromodomains and one C-terminal extraterminal domain (ET domain). BET proteins regulate chromatin reorganization via binding to acetylated histones. This gene is thought to play a role in the transcriptional regulation of spermatogenesis. Although referred to as testis-specific bromodomain (Brdt) protein, RT-PCR indicates that this gene is expressed in both mouse oocytes and testes. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]

Brdt 基因产物(2)

mRNA Protein Name
NM_054054.2 NP_473395.2 bromodomain testis-specific protein isoform A
NM_001079873.1 NP_001073342.1 bromodomain testis-specific protein isoform B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone binding IDA
IDA: 通过直接分析推断
12861021 MGI
enables histone reader activity IMP
IMP: 通过突变表型推断
22922464 MGI
enables lysine-acetylated histone binding IMP
IMP: 通过突变表型推断
22922464 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
20593818 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within chromatin remodeling IDA
IDA: 通过直接分析推断
12861021 MGI
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
19794495 MGI
involved in male meiosis I IMP
IMP: 通过突变表型推断
22922464 MGI
involved in male meiotic nuclear division IMP
IMP: 通过突变表型推断
22922464 MGI
acts upstream of or within positive effect positive regulation of gene expression IMP
IMP: 通过突变表型推断
22922464 MGI
involved in regulation of RNA splicing IMP
IMP: 通过突变表型推断
22570411 MGI
involved in sperm DNA condensation IMP
IMP: 通过突变表型推断
22922464 MGI
involved in spermatogenesis IMP
IMP: 通过突变表型推断
17728347 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
12861021 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Brdt 蛋白结构

Bromo_Brdt_I_like

Bromo_Brdt_I_like: cd05497 (25 - 131)

Bromo_Brdt_II_like

Bromo_Brdt_II_like: cd05498 (270 - 371)

BET

BET: pfam17035 (504 - 566)

BRD4_CDT

BRD4_CDT: pfam17105 (913 - 955)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 956 a.a.
蛋白主名 其他名称

bromodomain testis-specific protein

RING3-like protein

bromodomain-containing female sterile homeotic-like protein

female sterile homeotic-related gene 3

Brdt 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Brdt Q91Y44 Ccnt1 Mus musculus Q9QWV9
Anti Bait CoIP
22922464
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-112090 ABBV-744 Inhibitor 99.95% Phase 1
Pre-clinical Phase
生物活性分子 (18)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136570 GSK778 Inhibitor 98.93% 否
HY-136571 GSK046 Inhibitor 99.65% 否
HY-138563 GSK973 Inhibitor 99.97% 否
HY-114504 RVX-297 Inhibitor 95.00% 否
HY-112610 CF53 Inhibitor 99.81% 否
HY-130622 LT052 Inhibitor 98.77% 否
HY-160558 PLK1/BRD4-IN-3 Inhibitor 99.66% 否
HY-131061 BET bromodomain inhibitor 1 Inhibitor 99.91% 否
HY-126325 BY27 Inhibitor / 否
HY-149806 Bromodomain IN-2 Inhibitor / 否
HY-150684 GXH-II-052 Inhibitor / 否
HY-155680 BET BD2-IN-1 Inhibitor / 否
HY-150683 NC-III-49-1 Inhibitor / 否
HY-136794 SB-284851-BT Inhibitor / 否
HY-152213 BET-IN-13 Inhibitor / 否
HY-143471 WNY0824 Inhibitor / 否
HY-177140 CDD-1147 Inhibitor / 否
HY-136570A GSK778 hydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Brdt NCBI NCBI:676
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