TMEM123 - transmembrane protein 123 Gene

中文名称：跨膜蛋白 123

种属: Homo sapiens

同用名: KCT3; PORMIN; PORIMIN

关于 TMEM123

功能概要

该基因编码一种高度糖基化的跨膜蛋白，其胞外域具有高含量的苏氨酸和丝氨酸残基，类似于广义定义的称为粘蛋白的蛋白质类别。一些细胞类型暴露于抗 PORIMIN (促肿瘤受体诱导膜损伤) 抗体，在细胞表面交联这种蛋白质并诱导一种称为肿瘤的细胞死亡。肿瘤与细胞凋亡不同，其特征在于细胞膜完整性的丧失而没有 DNA 片段化。该基因产物被提议用作介导细胞死亡的细胞表面受体。[RefSeq 提供，2008 年 7 月]

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from Apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]