1. Gene
  2. ADCY9 - adenylate cyclase 9 Gene

ADCY9 - adenylate cyclase 9 Gene

中文名称:腺苷酸环化酶 9

种属: Homo sapiens

同用名: AC9; ACIX

基因 ID: 115 | 基因类型: protein coding

关于 ADCY9

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,953,387-4,116,442 (from NCBI)

This gene has 7 transcripts (splice variants), 270 orthologues and 17 paralogues. Ubiquitous expression in thyroid (RPKM 11.2), lung (RPKM 8.5) and 24 other tissues.


腺苷酸环化酶是一种膜结合酶,可催化 ATP 形成环状 AMP。它受 G 蛋白偶联受体家族、蛋白激酶和钙的调节。 9 型腺苷酸环化酶是一种广泛分布的腺苷酸环化酶,它受 β-肾上腺素能受体激活的刺激,但对毛喉素、钙和生长抑素不敏感。[RefSeq 提供,2008 年 7 月]

Adenylate Cyclase is a membrane bound Enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008]

ADCY9 基因产物(1)

mRNA Protein Name
NM_001116.4 NP_001107.2 adenylate cyclase type 9

ADCY9 蛋白结构


Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (386 - 571)


Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (1050 - 1242)

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  • 1353 a.a.
蛋白主名 其他名称

adenylate cyclase type 9

ATP pyrophosphate-lyase 9


疾病名称 别名
Chromosome 16p13.3 Duplication Syndrome

16p13.3 Microduplication Syndrome

Distal Duplication 16p

Distal Trisomy 16p

Telomeric Duplication 16p


Trisomy 16pter

Chromosome 16p13.3 Duplication

16p13.3 Duplication

Interstitial 16p13.3 Duplication


Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus


Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis


Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever


Cameroon Fever


Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever


Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Leber Congenital Amaurosis 1


Amaurosis Congenita Of Leber I


Retinal Blindness, Congenital


Leber Congenital Amaurosis Type I

Leber Congenital Amaurosis, Type 1

Amaurosis Congenita Of Leber, Type 1

Chromosome 16p13.3 Deletion Syndrome, Proximal

Rubinstein-Taybi Syndrome

Broad Thumb-Hallux Syndrome

Chromosome 16p13.3 Deletion Syndrome

Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion

Rubinstein Syndrome

Broad Thumbs-Halluces Syndrome


Rubinstein-Taybi Deletion Syndrome

Rsts Deletion Syndrome

Proximal Chromosome 16p13.3 Deletion Syndrome

16p13.3 Deletion Syndrome

Broad Thumbs And Great Toes, Characteristic Facies, And Intellectual Disability


Long Qt Syndrome 1

Romano-Ward Syndrome


Ward-Romano Syndrome


Ventricular Fibrillation With Prolonged Qt Interval


Long Qt Syndrome 1, Acquired, Susceptibility To

Long Qt Syndrome 1, Acquired

Romano-Ward Long Qt Syndrome

Long Qt Syndrome Type 1

Long Qt Syndrome-1

Acquired Susceptibility To Long Qt Syndrome 1

Qt Syndrome, Long, Type 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Canis familiaris ADCY9 VGNC VGNC:37626
Rattus norvegicus ADCY9 RGD RGD:1304747
Felis catus ADCY9 VGNC VGNC:59622
Bos taurus ADCY9 VGNC VGNC:25650
Mus musculus ADCY9 MGD MGI:108450
Macaca mulatta ADCY9 VGNC VGNC:99481