Mapk8 - mitogen-activated protein kinase 8 Gene

中文名称：丝裂原活化蛋白激酶 8

种属: Rattus norvegicus

同用名: JNK

关于 Mapk8

功能概要

该基因编码的蛋白质是 MAP 激酶家族的成员。 MAP激酶作为多种生化信号的整合点，参与多种细胞过程，如增殖、分化、转录调控和发育。这种激酶被各种细胞刺激激活，并靶向特定的转录因子，因此介导响应细胞刺激的即刻早期基因表达。发现肿瘤坏死因子 alpha (TNF-alpha) 对这种激酶的激活是 TNF-alpha 诱导的细胞凋亡所必需的。该激酶还参与紫外线辐射诱导的细胞凋亡，这被认为与细胞色素 c 介导的细胞死亡途径有关。 [RefSeq 提供，2012 年 7 月]

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced Apoptosis. This kinase is also involved in UV radiation induced Apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. [provided by RefSeq, Jul 2012]