Alox5ap - arachidonate 5-lipoxygenase activating protein Gene

中文名称：花生四烯酸 5-脂氧合酶激活蛋白

种属: Mus musculus

同用名: Flap

关于 Alox5ap

功能概要

预计该基因编码的蛋白具有多种功能，包括花生四烯酸结合活性；谷胱甘肽过氧化物酶活性；和谷胱甘肽转移酶活性。预计有助于花生四烯酸 5-脂氧合酶活性。在参与炎症反应的白三烯生物合成过程和白三烯生产的上游或内部起作用。位于核内。在淋巴系统中表达；肝;和椎骨。该基因的人类直系同源物与多种疾病有关，包括动脉疾病（多种）；哮喘;脑梗塞（多发）；乳腺癌;和脑瘫。与人类 ALOX5AP（花生四烯酸 5-脂氧合酶激活蛋白）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including arachidonic acid binding activity; Glutathione Peroxidase activity; and glutathione transferase activity. Predicted to contribute to arachidonate 5-lipoxygenase activity. Acts upstream of or within leukotriene biosynthetic process and leukotriene production involved in inflammatory response. Located in nucleus. Is expressed in hemolymphoid system; liver; and vertebra. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma; brain infarction (multiple); breast cancer; and cerebral palsy. Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein). [provided by Alliance of Genome Resources, Apr 2022]