2. Gene
  3. TAGAP - T cell activation RhoGTPase activating protein Gene

TAGAP - T cell activation RhoGTPase activating protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：T 细胞激活 RhoGTPase 激活蛋白

种属: Homo sapiens

同用名: FKSG15; IDDM21; TAGAP1; ARHGAP47

基因 ID: 117289 | 基因类型: protein coding

关于 TAGAP

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:159,034,481-159,044,991 (from NCBI)

This gene has 4 transcripts (splice variants), 229 orthologues and 1 paralogue. Biased expression in bone marrow (RPKM 44.8), lymph node (RPKM 19.7) and 10 other tissues.

功能概要

该基因编码 Rho GTPase 激活蛋白超家族的成员。编码的蛋白质可以作为 Rho GTP 酶激活蛋白发挥作用。该基因的改变可能与多种疾病有关，包括类风湿性关节炎、乳糜泻和多发性硬化症。交替剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

TAGAP 基因产物(4)

mRNA Protein Name
NM_001278733.2 NP_001265662.1 T-cell activation Rho GTPase-activating protein isoform d
NM_054114.5 NP_473455.2 T-cell activation Rho GTPase-activating protein isoform b
NM_138810.4 NP_620165.1 T-cell activation Rho GTPase-activating protein isoform c
NM_152133.3 NP_687034.1 T-cell activation Rho GTPase-activating protein isoform a

TAGAP 蛋白结构

RhoGAP

RhoGAP: RhoGAP domain (101 - 246)

  • 0
  • 200
  • 400
  • 600
  • 731 a.a.
蛋白主名 其他名称

T-cell activation Rho GTPase-activating protein

TAGAP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TAGAP Q8N103 HSF2BP Homo sapiens O75031
Y2H Array
32296183
种属内
TAGAP Q8N103 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

TAGAP 抗体

目录号 产品名 应用 反应物种
HY-P82396 TAGAP Antibody (YA2141) WB, IP Human, Rat
HY-P86294 TAGAP Antibody (YA5986) WB, FC, IP Human

关联疾病

疾病名称 别名
Type 1 Diabetes Mellitus 21

Diabetes Mellitus, Insulin-Dependent, 21

Iddm21

T1D21

Insulin-Dependent Diabetes Mellitus 21
Febrile Seizures, Familial, 10

FEB10

Familial Febrile Seizures 10

Convulsions, Familial Febrile, 10

Familial Febrile Convulsions 10

Febrile Convulsions, Familial, 10
Candidal Paronychia

Candidiasis Of Skin

Candidiasis Of Skin And Nails

Candidal Perionyxis
Auditory Agnosia
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14185 TAGAP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21060 Tagap Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27577 Tagap Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TAGAP VGNC VGNC:65942
Bos taurus TAGAP VGNC VGNC:35584
Rattus norvegicus TAGAP RGD RGD:1308618
Mus musculus TAGAP MGD MGI:1919786
Macaca mulatta TAGAP VGNC VGNC:78126
Canis familiaris TAGAP VGNC VGNC:47092
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