2. Gene
  3. Asah1 - N-acylsphingosine amidohydrolase 1 Gene

Asah1 - N-acylsphingosine amidohydrolase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: AC; Asah; 2310081N20Rik

基因 ID: 11886 | 基因类型: protein coding

关于 Asah1

功能概要

This gene encodes acid Ceramidase, an enzyme that plays a central role in ceramide metabolism. The encoded protein undergoes proteolytic processing to generate a heterodimeric enzyme comprised of alpha and beta subunits that catalyzes the hydrolysis of sphingolipid ceramide into sphingosine and free fatty acid. The homozygous disruption of this gene leads to embryonic lethality in mice whereas the heterozygous Animals exhibit a progressive lipid storage disease phenotype. [provided by RefSeq, Oct 2015]

Asah1 基因产物(1)

mRNA Protein Name
NM_019734.3 NP_062708.1 acid ceramidase preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables N-acylsphingosine amidohydrolase activity IDA
IDA: 通过直接分析推断
9653654 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to tumor necrosis factor IDA
IDA: 通过直接分析推断
10974027 MGI
involved in ceramide catabolic process IDA
IDA: 通过直接分析推断
9653654 MGI
involved in ceramide catabolic process IMP
IMP: 通过突变表型推断
23770692 MGI
involved in regulation of programmed necrotic cell death IMP
IMP: 通过突变表型推断
10974027 MGI
involved in sphingosine biosynthetic process IDA
IDA: 通过直接分析推断
9653654 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
22927646 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

acid ceramidase

ACDase

N-acylethanolamine hydrolase ASAH1

acid CDase

acylsphingosine deacylase

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-141866 Acid Ceramidase-IN-1 99.36% 否
HY-158783 SACLAC 99.70% 否
HY-RS01053 ASAH1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18163 Asah1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24637 Asah1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Asah1 NCBI NCBI:427
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