1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Ceramidase

Ceramidase (神经酰胺酶)

Ceramidases are a group of enzymes that catalyze the hydrolysis of ceramide, dihydroceramide, and phytoceramide into sphingosine (SPH), dihydrosphingosine (DHS), and phytosphingosine (PHS), respectively, along with a free fatty acid. Ceramide catabolism is controlled by ceramidases that are pivotal in the pathophysiology of these diseases of altered lipid homeostasis such as Alzheimer’s disease, type 2 diabetes-induced insulin resistance, cancer, and cardiovascular diseases. Ceramidases are classified into the acid, neutral, and alkaline ceramidase subtypes according to the pH optima for their catalytic activity.

Ceramidase 相关产品 (7):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0182
    Carmofur

    卡莫氟

    Inhibitor 99.95%
    Carmofur (HCFU) 是一种大鼠重组酸性神经酰胺酶 (acid ceramidase) 抑制剂,IC50 为 29 nM。Carmofur 也是 SARS-CoV-2 主要蛋白酶 (Mpro)、脂肪酸酰胺水解酶 (FAAH) 和 N-酰基乙醇胺酸酰胺酶 (NAAA) 抑制剂。Carmofur 具有抗癌、抗炎和抗病毒活性,可以用于 COVID-19 和急性肺损伤 (ALI) 的研究。
    Carmofur
  • HY-141866
    Acid Ceramidase-IN-1 99.36%
    Acid Ceramidase-IN-1 是一种有效的口服生物利用度酸性神经酰胺酶 (AC, ASAH-1) 抑制剂 (hAC IC50=0.166 μM)。Acid Ceramidase-IN-1 对小鼠具有良好的脑渗透性。
    Acid Ceramidase-IN-1
  • HY-103592
    ARN14974 Inhibitor 99.09%
    ARN14974 是一种酸性神经酰胺酶的抑制剂 (IC50=79 nM)。
    ARN14974
  • HY-137422
    D-erythro-MAPP ≥98.0%
    D-erythro-MAPP (D-e-MAPP) 是神经酰胺酶的抑制剂,其在体外的 IC50 值为 1-5 μM。
    D-erythro-MAPP
  • HY-153396
    Acid Ceramidase-IN-2 Inhibitor ≥99.0%
    Acid Ceramidase-IN-2 (compound 1) 是一种酸性神经酰胺酶 (ceramidase) 抑制剂,具有潜在的抗增殖和细胞抑制活性。此外,人酸性神经酰胺酶在前列腺癌细胞中过表达,说明 Acid Ceramidase-IN-2 有潜在的抗肿瘤作用。据研究,Acid Ceramidase-IN-2 的水解能够被 3 种 α-酮酰胺:GT85、GT98 和 GT99 在体外抑制。
    Acid Ceramidase-IN-2
  • HY-103359
    Ceranib1
    Ceranib1 是一种神经酰胺酶 (ceramidase) 抑制剂。Ceranib1 能抑制细胞神经酰胺酶对外源性神经酰胺类似物的活性,诱导多种神经酰胺物质的积累,降低鞘氨醇和 S1P 水平。Ceranib1 能抑制细胞卵巢癌细胞增殖。
    Ceranib1
  • HY-163106
    W000113414_I13 Agonist
    W000113414_I13 是一种酸性神经酰胺酶 (AC) 抑制剂。 W000113414_I13 对 AC 具有剂量依赖性抑制作用,IC50 值为 6.6?μM。 W000113414_I13可用于癌症的研究。
    W000113414_I13