2. Gene
  3. Rab27a - RAB27A, member RAS oncogene family Gene

Rab27a - RAB27A, member RAS oncogene family Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ash; 2210402C08Rik; 2410003M20Rik; 4933437C11Rik

基因 ID: 11891 | 基因类型: protein coding

关于 Rab27a

功能概要

The protein encoded by this gene is a member of the Rab family of proteins, which is the largest family within the Ras superfamily of GTPases. This gene product is thought to regulate vesicular transport, together with its specific effectors. Mutations in this gene cause several defects, including actin-based melanosome transport defects and immunodeficiency. Mutations in the human ortholog of this gene are associated with Griscelli syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Rab27a 基因产物(3)

mRNA Protein Name
NM_001301230.1 NP_001288159.1 ras-related protein Rab-27A
NM_001301232.1 NP_001288161.1 ras-related protein Rab-27A
NM_023635.6 NP_076124.1 ras-related protein Rab-27A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTP binding IDA
IDA: 通过直接分析推断
18940603 MGI
enables GTPase activity IDA
IDA: 通过直接分析推断
18940603 MGI
enables myosin V binding IPI
IPI: 通过物理相互作用推断
11266470 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11773082 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within blood coagulation IMP
IMP: 通过突变表型推断
10859366 MGI
acts upstream of or within cytotoxic T cell degranulation IMP
IMP: 通过突变表型推断
11266473 MGI
acts upstream of or within melanocyte differentiation IMP
IMP: 通过突变表型推断
2379821 MGI
acts upstream of or within melanosome transport IMP
IMP: 通过突变表型推断
11266473 MGI
acts upstream of or within natural killer cell degranulation IMP
IMP: 通过突变表型推断
11266473 MGI
acts upstream of or within pigment granule localization IMP
IMP: 通过突变表型推断
14978221 MGI
acts upstream of or within pigment granule transport IMP
IMP: 通过突变表型推断
15572405 MGI
acts upstream of or within pigmentation IMP
IMP: 通过突变表型推断
2379821 MGI
acts upstream of or within protein secretion IMP
IMP: 通过突变表型推断
29074498 MGI
acts upstream of or within vesicle-mediated transport IMP
IMP: 通过突变表型推断
10859366 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
14724135 MGI
located in melanosome IDA
IDA: 通过直接分析推断
11964381 MGI
located in photoreceptor outer segment IDA
IDA: 通过直接分析推断
11964381 MGI
located in secretory granule IMP
IMP: 通过突变表型推断
11266473 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ras-related protein Rab-27A

ashen

Rab27a 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Rab27a Q9ERI2 Sytl4 Mus musculus Q9R0Q1-1
Pull Down
18940603
种属间
Rab27a Q9ERI2 SYTL2 Homo sapiens Q9HCH5
GMS
18940603
种属间
Rab27a Q9ERI2 SYTL2 Homo sapiens Q9HCH5
Pull Down
18940603
种属间
Rab27a Q9ERI2 SYTL2 Homo sapiens Q9HCH5
X-Ray Diffraction
18940603
种属间
Rab27a Q9ERI2 SYTL5 Homo sapiens Q8TDW5
Pull Down
12051743
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-125792 Nexinhib20 Inhibitor 99.86% 否
HY-RS11537 RAB27A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16309 Rab27a Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rab27a NCBI NCBI:5873
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