2. Gene
  3. Atf2 - activating transcription factor 2 Gene

Atf2 - activating transcription factor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: mXBP; Atf-2; Creb2; CRE-BP; D130078H02Rik; Tg(Gzma-Klra1)7Wum

基因 ID: 11909 | 基因类型: protein coding

关于 Atf2

功能概要

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and protein dimerization activity. Involved in several processes, including animal organ development; histone acetylation; and intracellular signal transduction. Acts upstream of or within with a positive effect on regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adipose tissue development; fat cell differentiation; and positive regulation of transforming growth factor beta2 production. Located in membrane; nucleus; and site of double-strand break. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and musculoskeletal system. Used to study meconium aspiration syndrome and osteochondrodysplasia. Orthologous to human ATF2 (activating transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Atf2 基因产物(10)

mRNA Protein Name
NM_001025093.2 NP_001020264.1 cyclic AMP-dependent transcription factor ATF-2 isoform 1
NM_001284369.1 NP_001271298.1 cyclic AMP-dependent transcription factor ATF-2 isoform 2
NM_001284370.1 NP_001271299.1 cyclic AMP-dependent transcription factor ATF-2 isoform 4
NM_001284371.1 NP_001271300.1 cyclic AMP-dependent transcription factor ATF-2 isoform 4
NM_001284372.1 NP_001271301.1 cyclic AMP-dependent transcription factor ATF-2 isoform 5
NM_001284373.1 NP_001271302.1 cyclic AMP-dependent transcription factor ATF-2 isoform 5
NM_001284374.1 NP_001271303.1 cyclic AMP-dependent transcription factor ATF-2 isoform 6
NM_001284376.1 NP_001271305.1 cyclic AMP-dependent transcription factor ATF-2 isoform 3
NM_009715.3 NP_033845.1 cyclic AMP-dependent transcription factor ATF-2 isoform 2
NM_001284373.1 NP_001271302.1 cyclic AMP-dependent transcription factor ATF-2 isoform 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
12220541 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
19948881 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16405968 MGI
enables cAMP response element binding IDA
IDA: 通过直接分析推断
11231009 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
17767158 MGI
enables leucine zipper domain binding IPI
IPI: 通过物理相互作用推断
11231009 MGI
enables promoter-specific chromatin binding IDA
IDA: 通过直接分析推断
18802055 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
2138707 MGI
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
11231009 MGI
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
2138707 MGI
enables sequence-specific DNA binding IMP
IMP: 通过突变表型推断
15916964 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in BMP signaling pathway IMP
IMP: 通过突变表型推断
19948881 MGI
involved in DNA damage response IMP
IMP: 通过突变表型推断
15916964 MGI
involved in JNK cascade IMP
IMP: 通过突变表型推断
18802055 MGI
involved in MAPK cascade IMP
IMP: 通过突变表型推断
18802055 MGI
involved in NK T cell differentiation IMP
IMP: 通过突变表型推断
16223777 MGI
involved in abducens nucleus development IMP
IMP: 通过突变表型推断
21533046 MGI
acts upstream of or within adipose tissue development IGI
IGI: 通过遗传相互作用推断
19948881 MGI
involved in apoptotic process IMP
IMP: 通过突变表型推断
17189429 MGI
involved in apoptotic process involved in development IMP
IMP: 通过突变表型推断
21533046 MGI
involved in brainstem development IMP
IMP: 通过突变表型推断
21533046 MGI
involved in cellular lipid metabolic process IMP
IMP: 通过突变表型推断
21533046 MGI
involved in cellular response to anisomycin IDA
IDA: 通过直接分析推断
19584270 MGI
involved in cellular response to anisomycin IMP
IMP: 通过突变表型推断
17189429 MGI
acts upstream of or within positive effect cellular response to leucine starvation IMP
IMP: 通过突变表型推断
21533046 MGI
involved in cellular response to oxidative stress IMP
IMP: 通过突变表型推断
17699753 MGI
involved in cellular response to virus IDA
IDA: 通过直接分析推断
18802055 MGI
involved in detection of cell density IMP
IMP: 通过突变表型推断
17189429 MGI
involved in facial nucleus development IMP
IMP: 通过突变表型推断
21533046 MGI
involved in gene expression IDA
IDA: 通过直接分析推断
16405968 MGI
involved in gene expression IMP
IMP: 通过突变表型推断
18638549 MGI
involved in growth plate cartilage chondrocyte differentiation IMP
IMP: 通过突变表型推断
18638549 MGI
involved in growth plate cartilage chondrocyte proliferation IMP
IMP: 通过突变表型推断
18638549 MGI
involved in heart development IGI
IGI: 通过遗传相互作用推断
17699753 MGI
involved in hematopoietic progenitor cell differentiation IGI
IGI: 通过遗传相互作用推断
17699753 MGI
involved in hepatocyte apoptotic process IGI
IGI: 通过遗传相互作用推断
17699753 MGI
involved in hypoglossal nucleus development IMP
IMP: 通过突变表型推断
21533046 MGI
involved in in utero embryonic development IGI
IGI: 通过遗传相互作用推断
17699753 MGI
involved in in utero embryonic development IMP
IMP: 通过突变表型推断
17699753 MGI
involved in intrinsic apoptotic signaling pathway in response to hypoxia IMP
IMP: 通过突变表型推断
17189429 MGI
involved in liver development IGI
IGI: 通过遗传相互作用推断
17699753 MGI
involved in mRNA transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18638549 MGI
involved in motor neuron apoptotic process IMP
IMP: 通过突变表型推断
21533046 MGI
involved in neurofilament cytoskeleton organization IMP
IMP: 通过突变表型推断
21533046 MGI
acts upstream of or within outflow tract morphogenesis IMP
IMP: 通过突变表型推断
17767158 MGI
involved in p38MAPK cascade IGI
IGI: 通过遗传相互作用推断
17699753 MGI
involved in p38MAPK cascade IMP
IMP: 通过突变表型推断
19948881 MGI
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
16405968 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9748258 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
19948881 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
9748258 MGI
acts upstream of or within positive regulation of transforming growth factor beta2 production IMP
IMP: 通过突变表型推断
17767158 MGI
involved in protein import into nucleus IDA
IDA: 通过直接分析推断
32385399 MGI
involved in regulation of cell cycle checkpoint IMP
IMP: 通过突变表型推断
18638549 MGI
acts upstream of or within positive effect regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11231009 MGI
involved in response to organic cyclic compound IMP
IMP: 通过突变表型推断
18227516 MGI
involved in vacuole organization IMP
IMP: 通过突变表型推断
21533046 MGI
acts upstream of or within white fat cell differentiation IGI
IGI: 通过遗传相互作用推断
19948881 MGI
involved in white fat cell differentiation IGI
IGI: 通过遗传相互作用推断
19948881 MGI
involved in white fat cell differentiation IMP
IMP: 通过突变表型推断
19948881 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
15030387 MGI
located in nucleus IDA
IDA: 通过直接分析推断
19948881 MGI
located in site of double-strand break IMP
IMP: 通过突变表型推断
15916964 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cyclic AMP-dependent transcription factor ATF-2

cAMP response element-binding protein CRE-BP1

cAMP-dependent transcription factor ATF-2

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B1198 Piperonyl butoxide Inhibitor ≥98.0% 否
HY-B1198R Piperonyl butoxide (Standard) Inhibitor / 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-13241 Ralimetinib dimesylate 99.94% Phase 2
HY-13241A Ralimetinib Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-152860 Darizmetinib 99.94% 否
HY-117987 CPS-11 99.39% 否
HY-134963 SBI-0087702 99.55% 否
HY-B1198S Piperonyl butoxide-d9 Inhibitor / 否
HY-RS01128 ATF2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS05361 GDNF Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17003 Atf2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23446 Atf2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atf2 NCBI NCBI:1386
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