ATF2 - activating transcription factor 2 Gene

中文名称：激活转录因子 2

种属: Homo sapiens

同用名: HB16; CREB2; TREB7; CREB-2; CRE-BP1

基因 ID: 1386 | 基因类型: protein coding

关于 ATF2

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:175,072,259-175,168,203 (from NCBI)

This gene has 20 transcripts (splice variants), 214 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 19.6), brain (RPKM 14.7) and 25 other tissues.

功能概要

该基因编码的转录因子是 DNA 结合蛋白亮氨酸拉链家族的成员。编码的蛋白质已被确定为基于其执行机械上不同功能的能力的兼职蛋白质。这种蛋白质与 cAMP 反应元件 (CRE) 结合，这是一种八聚体回文结构。它与 c-Jun 形成同二聚体或异二聚体并刺激 CRE 依赖性转录。该蛋白也是一种组蛋白乙酰转移酶 (HAT) ，可在体外特异性乙酰化组蛋白 H2B 和 H4；因此它可能代表了一类序列特异性因子，它们通过对染色质成分的直接影响来激活转录。编码的蛋白质也可能参与细胞的 DNA 损伤反应，与其在转录调节中的作用无关。已经为该基因发现了几种选择性剪接的转录本变体[RefSeq 提供，2014 年 1 月]

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a Histone Acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]

ATF2 基因产物(6)

mRNA	Protein	Name
NM_001256090.2	NP_001243019.1	cyclic AMP-dependent transcription factor ATF-2 isoform 1
NM_001256091.2	NP_001243020.1	cyclic AMP-dependent transcription factor ATF-2 isoform 2
NM_001256092.2	NP_001243021.1	cyclic AMP-dependent transcription factor ATF-2 isoform 3
NM_001256093.2	NP_001243022.1	cyclic AMP-dependent transcription factor ATF-2 isoform 4
NM_001256094.2	NP_001243023.1	cyclic AMP-dependent transcription factor ATF-2 isoform 5
NM_001880.4	NP_001871.2	cyclic AMP-dependent transcription factor ATF-2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	16300731	GOA
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	8798441	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	19861239	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: 通过突变表型推断	2516827	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	19861239	GOA
enables cAMP response element binding	IDA IDA: 通过直接分析推断	19861239	GOA
enables cAMP response element binding protein binding	IDA IDA: 通过直接分析推断	19861239	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	2196176	GOA
enables histone H2B acetyltransferase activity	IDA IDA: 通过直接分析推断	10821277	GOA
enables histone H4 acetyltransferase activity	IDA IDA: 通过直接分析推断	10821277	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16511568	GOA
enables promoter-specific chromatin binding	IDA IDA: 通过直接分析推断	17267404	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	8440710	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	21098032	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IDA IDA: 通过直接分析推断	22304920	GOA
involved in DNA damage response	IMP IMP: 通过突变表型推断	15916964	GOA
involved in cellular response to leucine starvation	IDA IDA: 通过直接分析推断	17267404	GOA
involved in mitotic intra-S DNA damage checkpoint signaling	IMP IMP: 通过突变表型推断	15916964	GOA
involved in negative regulation of angiogenesis	IMP IMP: 通过突变表型推断	28977001	GOA
involved in negative regulation of transcription by RNA polymerase II	EXP EXP: 通过实验结果推断	11231009	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: 通过直接分析推断	17267404	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	10821277	GOA
involved in positive regulation of cardiac muscle myoblast proliferation	IDA IDA: 通过直接分析推断	22982025	GOA
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	28977001	GOA
involved in positive regulation of mitochondrial membrane permeability involved in apoptotic process	IMP IMP: 通过突变表型推断	22304920	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16300731	GOA
involved in regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	22304920	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19861239	GOA
involved in response to osmotic stress	IDA IDA: 通过直接分析推断	21098032	GOA
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: 通过直接分析推断	10821277	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of H4 histone acetyltransferase complex	IDA IDA: 通过直接分析推断	10821277	GOA
part of RNA polymerase II transcription regulator complex	EXP EXP: 通过实验结果推断	11231009	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: 通过物理相互作用推断	20102225	GOA
located in chromatin	IDA IDA: 通过直接分析推断	23729669	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	22304920	GOA
located in mitochondrial outer membrane	IDA IDA: 通过直接分析推断	22304920	GOA
located in nucleus	EXP EXP: 通过实验结果推断	11231009	GOA
located in nucleus	IDA IDA: 通过直接分析推断	8798441	GOA
located in site of double-strand break	IDA IDA: 通过直接分析推断	15916964	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ATF2 蛋白结构

bZIP_1

0
100
200
300
400
505 a.a.

蛋白主名

其他名称

cyclic AMP-dependent transcription factor ATF-2

cAMP response element-binding protein CRE-BP1

ATF2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ATF2	P15336	FOS	Homo sapiens	Q6FG41	Y2H Prey Pooling	25416956
种属内	ATF2	P15336	FOS	Homo sapiens	Q6FG41	Validated Y2H	25416956
种属内	ATF2	P15336	FOS	Homo sapiens	Q6FG41	Y2H Array	25416956
种属内	ATF2	P15336	BATF3	Homo sapiens	Q9NR55	Peptide Array	20102225
种属内	ATF2	P15336	BANP	Homo sapiens	Q8N9N5-2	Y2H Array	32296183
种属内	ATF2	P15336	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
种属内	ATF2	P15336	BANP	Homo sapiens	Q8N9N5-2	Y2H Prey Pooling	32296183
种属内	ATF2	P15336	JUN	Homo sapiens	P05412	Anti Tag CoIP	33961781
种属内	ATF2	P15336	JUN	Homo sapiens	P05412	Anti Tag CoIP	28514442
种属内	ATF2	P15336	JUN	Homo sapiens	P05412	FRET	23661758
种属内	ATF2	P15336	JUN	Homo sapiens	P05412	PLA	20511396
种属内	ATF2	P15336	JUN	Homo sapiens	P05412	Display Tech	20195357
种属内	ATF2	P15336	FOS	Homo sapiens	P01100	Peptide Array	20102225
种属内	ATF2	P15336	JUN	Homo sapiens	P05412	TAP	20195357
种属内	ATF2	P15336	JUN	Homo sapiens	P05412	CoIP	10327051
种属内	ATF2	P15336	JUN	Homo sapiens	P05412	Peptide Array	20102225
种属内	ATF2	P15336	BACH1	Homo sapiens	O14867	FRET	23661758
种属内	ATF2	P15336	BACH1	Homo sapiens	O14867	Peptide Array	20102225
种属内	ATF2	P15336	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
种属内	ATF2	P15336	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
种属内	ATF2	P15336	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
种属内	ATF2	P15336	VRK1	Homo sapiens	Q99986	Anti Tag CoIP	15105425
种属内	ATF2	P15336	VRK1	Homo sapiens	Q99986	IF	15105425
种属内	ATF2	P15336	KIFC3	Homo sapiens	Q9BVG8	Y2H Prey Pooling	25416956
种属内	ATF2	P15336	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
种属内	ATF2	P15336	RNF4	Homo sapiens	P78317	Validated Y2H	32296183
种属内	ATF2	P15336	RNF4	Homo sapiens	P78317	Y2H Array	32296183
种属内	ATF2	P15336	CENPQ	Homo sapiens	Q7L2Z9	Validated Y2H	32296183
种属内	ATF2	P15336	CENPQ	Homo sapiens	Q7L2Z9	Y2H Array	32296183
种属内	ATF2	P15336	CITED1	Homo sapiens	Q99966	CoIP	10327051
种属内	ATF2	P15336	JUND	Homo sapiens	P17535	Anti Tag CoIP	33961781
种属内	ATF2	P15336	JUND	Homo sapiens	P17535	Anti Tag CoIP	28514442
种属内	ATF2	P15336	JUND	Homo sapiens	P17535	Peptide Array	20102225
种属内	ATF2	P15336	FOSB	Homo sapiens	P53539	Validated Y2H	32296183
种属内	ATF2	P15336	FOSB	Homo sapiens	P53539	Y2H Prey Pooling	32296183
种属内	ATF2	P15336	FOSB	Homo sapiens	P53539	Y2H Array	32296183
种属内	ATF2	P15336	SPOPL	Homo sapiens	Q6IQ16	Validated Y2H	32296183
种属内	ATF2	P15336	SPOPL	Homo sapiens	Q6IQ16	Y2H Array	32296183
种属内	ATF2	P15336	SPOPL	Homo sapiens	Q6IQ16	Y2H Prey Pooling	32296183
种属内	ATF2	P15336	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
种属内	ATF2	P15336	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
种属内	ATF2	P15336	EXOSC8	Homo sapiens	Q96B26	Y2H Array	25416956
种属内	ATF2	P15336	EXOSC8	Homo sapiens	Q96B26	Validated Y2H	25416956
种属内	ATF2	P15336	FOSL2	Homo sapiens	P15408	Y2H Prey Pooling	32296183
种属内	ATF2	P15336	FOSL2	Homo sapiens	P15408	Peptide Array	20102225
种属内	ATF2	P15336	FOSL2	Homo sapiens	P15408	Validated Y2H	32296183
种属内	ATF2	P15336	FOSL2	Homo sapiens	P15408	Y2H Array	32296183
种属内	ATF2	P15336	ATF4	Homo sapiens	P18848	FRET	23661758
种属内	ATF2	P15336	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
种属内	ATF2	P15336	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
种属内	ATF2	P15336	SYT-SSX2	Homo sapiens	A4PIW0	Anti Bait CoIP	22439931
种属内	ATF2	P15336	SYT-SSX2	Homo sapiens	A4PIW0	Anti Tag CoIP	22439931
种属内	ATF2	P15336	NFATC1	Homo sapiens	O95644	Pull Down	25609649
种属内	ATF2	P15336	ATF3	Homo sapiens	P18847	FRET	23661758
种属内	ATF2	P15336	ATF3	Homo sapiens	P18847	Peptide Array	20102225
种属内	ATF2	P15336	MAPK9	Homo sapiens	P45984	Y2H Array	31515488
种属内	ATF2	P15336	MAPK9	Homo sapiens	P45984	Y2H Prey Pooling	25416956
种属内	ATF2	P15336	MAPK9	Homo sapiens	P45984	Validated Y2H	25416956
种属内	ATF2	P15336	MAPK9	Homo sapiens	P45984	Y2H Prey Pooling	32296183
种属内	ATF2	P15336	MAPK9	Homo sapiens	P45984	Validated Y2H	32296183
种属内	ATF2	P15336	MAPK9	Homo sapiens	P45984	Y2H Array	25416956
种属内	ATF2	P15336	MAPK9	Homo sapiens	P45984	Y2H Array	32296183
种属内	ATF2	P15336	CEBPG	Homo sapiens	P53567	Peptide Array	20102225
种属内	ATF2	P15336	DDIT3	Homo sapiens	P35638	Peptide Array	20102225
种属内	ATF2	P15336	FOSL1	Homo sapiens	P15407	FRET	23661758
种属内	ATF2	P15336	JUNB	Homo sapiens	P17275	Anti Tag CoIP	33961781
种属内	ATF2	P15336	JUNB	Homo sapiens	P17275	Complementation	16511568
种属内	ATF2	P15336	BATF	Homo sapiens	Q16520	FRET	23661758
种属内	ATF2	P15336	ATF7	Homo sapiens	P17544	Peptide Array	20102225
种属内	ATF2	P15336	ATF7	Homo sapiens	P17544	Anti Tag CoIP	33961781
种属内	ATF2	P15336	SUMO1	Homo sapiens	P63165	Y2H Array	32296183
种属内	ATF2	P15336	SUMO1	Homo sapiens	P63165	Validated Y2H	32296183
种属内	ATF2	P15336	SUMO1	Homo sapiens	P63165	Y2H Prey Pooling	32296183
种属内	ATF2	P15336	LHX8	Homo sapiens	Q68G74	Y2H Prey Pooling	32296183
种属内	ATF2	P15336	LHX8	Homo sapiens	Q68G74	Validated Y2H	32296183
种属内	ATF2	P15336	LHX8	Homo sapiens	Q68G74	Y2H Array	32296183
种属内	ATF2	P15336	FOS	Homo sapiens	P01100	TAP	20195357
种属内	ATF2	P15336	FOS	Homo sapiens	P01100	Y2H Array	32296183
种属内	ATF2	P15336	FOS	Homo sapiens	P01100	Y2H Prey Pooling	32296183
种属间	ATF2	P15336	MDV005	Gallid herpesvirus 2	Q9DGW5	Peptide Array	20102225
种属间	ATF2	P15336	HBZ	Human T-cell leukemia virus 1	P0C746	Peptide Array	20102225

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ATF2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74408	ATF2 Protein, Human (sf9, His-GST)	P15336 (M1-S505)	≥95%

ATF2 抗体

目录号	产品名	应用	反应物种
HY-P80552	ATF2 Antibody (YA606)	WB	Human, Mouse, Rat
HY-P80793	Phospho-ATF2 (Thr71) Antibody (YA224)	WB, ICC/IF, IP	Human, Mouse
HY-P85048	ATF-2 Antibody (YA4740)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse

关联疾病

疾病名称

别名

Cardiomyopathy, Familial Hypertrophic, 25

Hypertrophic Cardiomyopathy 25	CMH25
Cardiomyopathy, Hypertrophic, 25	Cardiomyopathy Familial Hypertrophic 25
Cardiomyopathy, Familial Hypertrophic 25	Cardiomyopathy, Hypertrophic, Type 25

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Epidermolysis Bullosa Simplex

Ebs	Epidermolysis Bullosa Intraepidermic
Epidermolytic Epidermolysis Bullosa

Pick Disease Of Brain

Pick Disease	Pick'S Disease
Pick Disease Of The Brain	Lobar Atrophy Of Brain
Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions	Behavioral Variant Of Frontotemporal Dementia
Dementia In Pick'S Disease	Lobar Atrophy Of The Brain
Bvftd	Bv-Ftd
PIDB	Picks Disease

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1	PKD1
Adpkd	Polycystic Kidney Disease, Adult, Type I
Apkd1	Potter Type Iii Polycystic Kidney Disease
Polycystic Kidney Disease, Adult	Potter Type Iii Polycystic Kidney Disease, Formerly
Polycystic Kidney Disease, Type 1	Adpkd1
Adult Polycystic Kidney Disease Type 1	Autosomal Dominant Polycystic Kidney Disease 1
Pkd-1	Polycystic Kidney Disease Adult
Polycystic Kidney Disease Type I	Polycystic Kidneys
Polycystic Kidney Disease, Adult Type I	Polycystic Kidney Type 1 Autosomal Dominant Disease
Kidney Disease, Polycystic, Type 1	Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Type 1 Autosomal Dominant Disease	Polycystic Kidney Diseases

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-B1198	Piperonyl butoxide	Inhibitor	≥98.0%	否
HY-B1198R	Piperonyl butoxide (Standard)	Inhibitor	/	否

目录号	产品名	作用方式	纯度	Phase
HY-13241	Ralimetinib dimesylate		99.94%	Phase 2
HY-13241A	Ralimetinib	Inhibitor	/	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-152860	Darizmetinib		99.94%	否
HY-117987	CPS-11		99.39%	否
HY-134963	SBI-0087702		99.55%	否
HY-B1198S	Piperonyl butoxide-d9	Inhibitor	/	否
HY-RS01128	ATF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS05361	GDNF Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17003	Atf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23446	Atf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	ATF2	VGNC	VGNC:68500
Macaca mulatta	ATF2	VGNC	VGNC:70169
Bos taurus	ATF2	VGNC	VGNC:26240
Mus musculus	ATF2	MGD	MGI:109349
Rattus norvegicus	ATF2	RGD	RGD:621862
Canis familiaris	ATF2	VGNC	VGNC:38208
Others	ATF2	NCBI

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