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  3. ATF2 - activating transcription factor 2 Gene

ATF2 - activating transcription factor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：激活转录因子 2

种属: Homo sapiens

同用名: HB16; CREB2; TREB7; CREB-2; CRE-BP1

基因 ID: 1386 | 基因类型: protein coding

关于 ATF2

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:175,072,259-175,168,203 (from NCBI)

This gene has 20 transcripts (splice variants), 214 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 19.6), brain (RPKM 14.7) and 25 other tissues.

功能概要

该基因编码的转录因子是 DNA 结合蛋白亮氨酸拉链家族的成员。编码的蛋白质已被确定为基于其执行机械上不同功能的能力的兼职蛋白质。这种蛋白质与 cAMP 反应元件 (CRE) 结合，这是一种八聚体回文结构。它与 c-Jun 形成同二聚体或异二聚体并刺激 CRE 依赖性转录。该蛋白也是一种组蛋白乙酰转移酶 (HAT) ，可在体外特异性乙酰化组蛋白 H2B 和 H4；因此它可能代表了一类序列特异性因子，它们通过对染色质成分的直接影响来激活转录。编码的蛋白质也可能参与细胞的 DNA 损伤反应，与其在转录调节中的作用无关。已经为该基因发现了几种选择性剪接的转录本变体[RefSeq 提供，2014 年 1 月]

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a Histone Acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]

ATF2 基因产物(6)

mRNA Protein Name
NM_001256090.2 NP_001243019.1 cyclic AMP-dependent transcription factor ATF-2 isoform 1
NM_001256091.2 NP_001243020.1 cyclic AMP-dependent transcription factor ATF-2 isoform 2
NM_001256092.2 NP_001243021.1 cyclic AMP-dependent transcription factor ATF-2 isoform 3
NM_001256093.2 NP_001243022.1 cyclic AMP-dependent transcription factor ATF-2 isoform 4
NM_001256094.2 NP_001243023.1 cyclic AMP-dependent transcription factor ATF-2 isoform 5
NM_001880.4 NP_001871.2 cyclic AMP-dependent transcription factor ATF-2 isoform 1

ATF2 蛋白结构

bZIP_1

bZIP_1: bZIP transcription factor (352 - 411)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
蛋白主名 其他名称

cyclic AMP-dependent transcription factor ATF-2

cAMP response element-binding protein CRE-BP1

重组 ATF2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74408 ATF2 Protein, Human (sf9, His-GST) P15336 (M1-S505) ≥95%

关联疾病

疾病名称 别名
Cardiomyopathy, Familial Hypertrophic, 25

Hypertrophic Cardiomyopathy 25

CMH25

Cardiomyopathy, Hypertrophic, 25

Cardiomyopathy Familial Hypertrophic 25

Cardiomyopathy, Familial Hypertrophic 25

Cardiomyopathy, Hypertrophic, Type 25
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant
Epidermolysis Bullosa Simplex

Ebs

Epidermolysis Bullosa Intraepidermic

Epidermolytic Epidermolysis Bullosa
Pick Disease Of Brain

Pick Disease

Pick'S Disease

Pick Disease Of The Brain

Lobar Atrophy Of Brain

Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions

Behavioral Variant Of Frontotemporal Dementia

Dementia In Pick'S Disease

Lobar Atrophy Of The Brain

Bvftd

Bv-Ftd

PIDB

Picks Disease
Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1

PKD1

Adpkd

Polycystic Kidney Disease, Adult, Type I

Apkd1

Potter Type Iii Polycystic Kidney Disease

Polycystic Kidney Disease, Adult

Potter Type Iii Polycystic Kidney Disease, Formerly

Polycystic Kidney Disease, Type 1

Adpkd1

Adult Polycystic Kidney Disease Type 1

Autosomal Dominant Polycystic Kidney Disease 1

Pkd-1

Polycystic Kidney Disease Adult

Polycystic Kidney Disease Type I

Polycystic Kidneys

Polycystic Kidney Disease, Adult Type I

Polycystic Kidney Type 1 Autosomal Dominant Disease

Kidney Disease, Polycystic, Type 1

Polycystic Kidney, Autosomal Dominant

Polycystic Kidney, Type 1 Autosomal Dominant Disease

Polycystic Kidney Diseases
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-13241 Ralimetinib dimesylate 99.91% Phase 2
HY-13241A Ralimetinib Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-117987 CPS-11 99.39% 否
HY-RS01128 ATF2 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ATF2 VGNC VGNC:68500
Macaca mulatta ATF2 VGNC VGNC:70169
Bos taurus ATF2 VGNC VGNC:26240
Mus musculus ATF2 MGD MGI:109349
Rattus norvegicus ATF2 RGD RGD:621862
Canis familiaris ATF2 VGNC VGNC:38208
Others ATF2 NCBI
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