2. Gene
  3. Axin1 - axin 1 Gene

Axin1 - axin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Fu; Kb; Ki; Axin; fused; kinky; knobbly

基因 ID: 12005 | 基因类型: protein coding

关于 Axin1

功能概要

Enables several functions, including SMAD binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in positive regulation of JNK cascade; positive regulation of protein modification process; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including chordate embryonic development; negative regulation of macromolecule metabolic process; and regulation of protein metabolic process. Located in several cellular components, including cell cortex; cytoplasmic vesicle; and microtubule Cytoskeleton. Part of Wnt signalosome and beta-catenin destruction complex. Is expressed in several structures, including alimentary system; forebrain; genitourinary system; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human AXIN1 (axin 1). [provided by Alliance of Genome Resources, Apr 2022]

Axin1 基因产物(5)

mRNA Protein Name
NM_001159598.2 NP_001153070.2 axin-1 isoform 1
NM_001394381.1 NP_001381310.1 axin-1 isoform 2
NM_001394382.1 NP_001381311.1 axin-1 isoform 1
NM_001394389.1 NP_001381318.1 axin-1 isoform 1
NM_009733.3 NP_033863.3 axin-1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables I-SMAD binding IDA
IDA: 通过直接分析推断
16601693 MGI
enables I-SMAD binding IPI
IPI: 通过物理相互作用推断
16601693 MGI
enables R-SMAD binding IPI
IPI: 通过物理相互作用推断
16601693 MGI
enables beta-catenin binding IPI
IPI: 通过物理相互作用推断
10318824 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
9920888 MGI
enables p53 binding IPI
IPI: 通过物理相互作用推断
15526030 MGI
enables protein binding IDA
IDA: 通过直接分析推断
10318824 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9920888 MGI
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
15579909 MGI
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
17681137 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
10318824 MGI
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
16601693 MGI
enables ubiquitin-like ligase-substrate adaptor activity IMP
IMP: 通过突变表型推断
16601693 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Wnt signaling pathway IDA
IDA: 通过直接分析推断
11113207 MGI
acts upstream of or within Wnt signaling pathway IPI
IPI: 通过物理相互作用推断
11113207 MGI
acts upstream of or within axial mesoderm development IMP
IMP: 通过突变表型推断
9230313 MGI
acts upstream of or within axial mesoderm formation IMP
IMP: 通过突变表型推断
9230313 MGI
acts upstream of or within canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
10937998 MGI
acts upstream of or within canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
19075000 MGI
acts upstream of or within cytoplasmic microtubule organization IGI
IGI: 通过遗传相互作用推断
14734535 MGI
acts upstream of or within dorsal/ventral axis specification IDA
IDA: 通过直接分析推断
10330403 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: 通过突变表型推断
18316368 MGI
acts upstream of or within epigenetic programming in the zygotic pronuclei IMP
IMP: 通过突变表型推断
12601169 MGI
acts upstream of or within head development IMP
IMP: 通过突变表型推断
21344612 MGI
acts upstream of or within in utero embryonic development IGI
IGI: 通过遗传相互作用推断
19204372 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
19204372 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IDA
IDA: 通过直接分析推断
9230313 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
15579909 MGI
acts upstream of or within negative regulation of fat cell differentiation IDA
IDA: 通过直接分析推断
10937998 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: 通过直接分析推断
18076571 MGI
acts upstream of or within negative regulation of protein metabolic process IDA
IDA: 通过直接分析推断
10330403 MGI
acts upstream of or within negative regulation of transcription elongation by RNA polymerase II IDA
IDA: 通过直接分析推断
10318824 MGI
acts upstream of or within nucleocytoplasmic transport IDA
IDA: 通过直接分析推断
14981260 MGI
acts upstream of or within positive regulation of JNK cascade IMP
IMP: 通过突变表型推断
18316368 MGI
involved in positive regulation of JNK cascade IMP
IMP: 通过突变表型推断
17681137 MGI
acts upstream of or within positive regulation of JUN kinase activity IDA
IDA: 通过直接分析推断
12878610 MGI
acts upstream of or within positive regulation of JUN kinase activity IMP
IMP: 通过突变表型推断
12878610 MGI
involved in positive regulation of peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
11955436 MGI
involved in positive regulation of peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
11955436 MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
16601693 MGI
involved in positive regulation of protein kinase activity IDA
IDA: 通过直接分析推断
15526030 MGI
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
10330403 MGI
acts upstream of or within positive regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
16601693 MGI
acts upstream of or within positive regulation of protein ubiquitination IGI
IGI: 通过遗传相互作用推断
16601693 MGI
acts upstream of or within positive regulation of protein ubiquitination IMP
IMP: 通过突变表型推断
16601693 MGI
involved in positive regulation of protein ubiquitination IMP
IMP: 通过突变表型推断
16601693 MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
16601693 MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
16601693 MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
16601693 MGI
acts upstream of or within positive regulation of ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
16601693 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: 通过突变表型推断
12601169 MGI
acts upstream of or within protein catabolic process IDA
IDA: 通过直接分析推断
12717450 MGI
acts upstream of or within protein polyubiquitination IDA
IDA: 通过直接分析推断
16601693 MGI
acts upstream of or within regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
14981260 MGI
acts upstream of or within regulation of protein phosphorylation IGI
IGI: 通过遗传相互作用推断
14734535 MGI
acts upstream of or within sensory perception of sound IMP
IMP: 通过突变表型推断
21003499 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Wnt signalosome IDA
IDA: 通过直接分析推断
22899650 MGI
part of beta-catenin destruction complex IDA
IDA: 通过直接分析推断
10318824 MGI
located in cell cortex IDA
IDA: 通过直接分析推断
10330403 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
11113207 MGI
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
11113207 MGI
located in microtubule cytoskeleton IDA
IDA: 通过直接分析推断
14734535 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
10330403 MGI
part of protein-containing complex IDA
IDA: 通过直接分析推断
16601693 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

axin-1

axis inhibition protein 1

protein Fused

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-147245 Basroparib Inhibitor 98.49% Phase 1
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-107528 FRATtide Inhibitor / 否
HY-141543 YW2065 Inhibitor 99.91% 否
HY-173349 TDI-012804 Inhibitor / 否
HY-RS01291 AXIN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22402 Axin1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Axin1 NCBI NCBI:8312
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