Bdkrb2 - bradykinin receptor, beta 2 Gene

中文名称：缓激肽受体， β 2

种属: Mus musculus

同用名: B2; B2R; BK2; B(2); BK-2; BK2R; BKR2; BRB2

关于 Bdkrb2

功能概要

预计该基因编码的蛋白具有多种功能，包括 G 蛋白偶联受体结合活性；缓激肽受体活性；和蛋白质异二聚化活性。在几个过程的上游或内部起作用，包括响应 p53 类介质对渗透压的内在凋亡信号通路的负调节；肽基丝氨酸磷酸化的负调节；和血管扩张。预计位于高尔基体和核内体。预计在质膜上有活性。在集合管和后肾中表达。与哮喘有关的该基因的人类直系同源物；慢性阻塞性肺疾病;高血压;和鼻炎。与人 BDKRB2（缓激肽受体 B2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including G protein-coupled receptor binding activity; Bradykinin Receptor activity; and protein heterodimerization activity. Acts upstream of or within several processes, including negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator; negative regulation of peptidyl-serine phosphorylation; and vasodilation. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in plasma membrane. Is expressed in collecting duct and metanephros. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Orthologous to human BDKRB2 (Bradykinin Receptor B2). [provided by Alliance of Genome Resources, Apr 2022]