BDKRB2 - bradykinin receptor B2 Gene

中文名称：缓激肽受体 B2

种属: Homo sapiens

同用名: B2R; BK2; BK-2; BKR2; BRB2

基因 ID: 624 | 基因类型: protein coding

关于 BDKRB2

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:96,204,839-96,244,164 (from NCBI)

This gene has 3 transcripts (splice variants), 362 orthologues and 7 paralogues. Broad expression in urinary bladder (RPKM 13.5), gall bladder (RPKM 13.3) and 16 other tissues.

功能概要

该基因编码缓激肽受体。 9 aa 缓激肽肽引起许多反应，包括血管舒张、水肿、平滑肌痉挛和疼痛纤维刺激。缓激肽在被创伤和炎症等病理生理条件激活后释放，并与其激肽受体 B1 和 B2 结合。 B2 受体与刺激磷脂酰肌醇-钙第二信使系统的 G 蛋白相关。[RefSeq 提供，2020 年 4 月]

This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. [provided by RefSeq, Apr 2020]

BDKRB2 基因产物(2)

mRNA	Protein	Name
NM_001379692.1	NP_001366621.1	B2 bradykinin receptor
NM_000623.4	NP_000614.1	B2 bradykinin receptor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables bradykinin receptor activity	IDA IDA: 通过直接分析推断	1314587	GOA
enables protease binding	IPI IPI: 通过物理相互作用推断	17077303	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18672896	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	10993080	GOA
enables type 1 angiotensin receptor binding	IPI IPI: 通过物理相互作用推断	10993080	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in arachidonate secretion	IDA IDA: 通过直接分析推断	17077303	GOA
involved in vasodilation	IDA IDA: 通过直接分析推断	4322742	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endosome	IDA IDA: 通过直接分析推断	17077303	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	17077303	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BDKRB2 蛋白结构

7tm_1

0
100
200
300
391 a.a.

蛋白主名

其他名称

B2 bradykinin receptor

BK-2 receptor

BDKRB2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BDKRB2	P30411	P01042-PRO_0000006688	Homo sapiens	P01042-PRO_0000006688	SPA	23597562

种属间: 跨种属相互作用 种属内: 同种属相互作用

BDKRB2 抗体

目录号	产品名	应用	反应物种
HY-P81722	BDKRB2 Antibody (YA1467)	WB, IP	Human, Mouse

关联疾病

疾病名称

别名

Placenta Accreta

Angioedema, Hereditary, 1

Hereditary Angioedema Type I	Hereditary Angioneurotic Edema
Hane	C1 Esterase Inhibitor Deficiency
Angioedema, Hereditary, 1 And 2	HAE1
Angioneurotic Edema, Hereditary	Angioedema, Hereditary, Type I
Hereditary Angioedema Type 2	Hae 2
Hae-Ii	Hereditary Angioneurotic Edema Type 2
Angioedema, Hereditary	HAE
Angioedema, Hereditary, Types I And Ii	Hereditary Angioedema, Type Ii
Angioedema, Hereditary, Type 1	Angioedemas, Hereditary
Hereditary C1 Esterase Inhibitor Deficiency - Dysfunctional Factor	Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor
Hereditary Angioedema Types I And Ii

Angioedema

Angioneurotic Oedema	Quincke'S Edema
Angioneurotic Edema	Giant Urticaria

Brucella Abortus Brucellosis

Brucellosis, Bovine

Hereditary Angioedema

Hereditary Angioneurotic Edema	Hereditary Angioedema Type 1
Hane	Angioedema, Hereditary
Hae	Angioedemas, Hereditary
Deficiency Of C1 Esterase Inhibitor	C1 Esterase Inhibitor Deficiency
C1 Inhibitor Deficiency	Familial Angioneurotic Edema
Hereditary Bradykinine-Induced Angioedema	Hereditary Non Histamine-Induced Angioedema
Hae 1	Hae-I
Hereditary Angioneurotic Edema Type 1	Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor
Hereditary Angioedema Types I And Ii	Hereditary Angioneurotic Oedema
Familial Angioedema	Hae - [Hereditary Angioneurotic Oedema]
Bannister Disease, Hereditary	Quincke Disease Or Oedema
Hereditary Quincke Oedema

Brain Edema

Intracranial Swelling	Wet Brain
Cerebral Edema

End Stage Renal Disease

End Stage Renal Failure	End-Stage Kidney Disease
Kidney Failure, Chronic	Chronic Kidney Disease Stage 5

C1 Inhibitor Deficiency

Quincke Edema	Angioedemas, Hereditary
Angioedema

Acquired Angioedema

Acquired C1 Inhibitor Deficiency	Angioedema, Acquired
Aae	Acquired Angioneurotic Edema
Acquired Bradykinine-Induced Angioedema	Acquired Non Histamine-Induced Angioedema
Acquired Angioneurotic Oedema	Aae - [Acquired Angioneurotic Oedema]

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01457	BDKRB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS01458	Bdkrb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS01459	Bdkrb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	BDKRB2	RGD	RGD:2201
Bos taurus	BDKRB2	VGNC	VGNC:26460
Canis familiaris	BDKRB2	VGNC	VGNC:38425
Mus musculus	BDKRB2	MGD	MGI:102845

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BDKRB2 - bradykinin receptor B2 Gene

关于 BDKRB2

功能概要

BDKRB2 基因产物(2)

BDKRB2 蛋白结构

BDKRB2 蛋白互作信息

BDKRB2 抗体

关联疾病

直系同源

热门区域

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BDKRB2 - bradykinin receptor B2 Gene

关于 BDKRB2

功能概要

BDKRB2 基因产物(2)

BDKRB2 蛋白结构

BDKRB2 蛋白互作信息

BDKRB2 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z