2. Gene
  3. ALKBH2 - alkB homolog 2, alpha-ketoglutarate dependent dioxygenase Gene

ALKBH2 - alkB homolog 2, alpha-ketoglutarate dependent dioxygenase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：alkB 同系物 2，α-酮戊二酸依赖性双加氧酶

种属: Homo sapiens

同用名: ABH2

基因 ID: 121642 | 基因类型: protein coding

关于 ALKBH2

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,088,189-109,093,472 (from NCBI)

This gene has 8 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in ovary (RPKM 6.9), endometrium (RPKM 5.8) and 25 other tissues.

功能概要

大肠杆菌 AlkB 蛋白通过修复单链 DNA 中产生的特定 DNA 损伤来防止甲基化剂的细胞毒性。 ALKBH2 和 ALKBH3 (MIM 610603) 是大肠杆菌 AlkB 同源物，可催化去除 1-甲基腺嘌呤和 3-甲基胞嘧啶 (Duncan 等人，2002 [PubMed 12486230]) 。[OMIM 提供，2008 年 3 月]

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]

ALKBH2 基因产物(5)

mRNA Protein Name
NM_001001655.3 NP_001001655.1 DNA oxidative demethylase ALKBH2 isoform 1
NM_001145374.2 NP_001138846.1 DNA oxidative demethylase ALKBH2 isoform 1
NM_001145375.2 NP_001138847.1 DNA oxidative demethylase ALKBH2 isoform 1
NM_001205179.2 NP_001192108.1 DNA oxidative demethylase ALKBH2 isoform 2
NM_001205180.2 NP_001192109.1 DNA oxidative demethylase ALKBH2 isoform 2

ALKBH2 蛋白结构

2OG-FeII_Oxy_2

2OG-FeII_Oxy_2: 2OG-Fe(II) oxygenase superfamily (74 - 254)

  • 0
  • 100
  • 200
  • 261 a.a.
蛋白主名 其他名称

DNA oxidative demethylase ALKBH2

2OG-Fe(II) oxy DC1

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00604 ALKBH2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ALKBH2 VGNC VGNC:25833
Felis catus ALKBH2 VGNC VGNC:59750
Rattus norvegicus ALKBH2 RGD RGD:1306377
Mus musculus ALKBH2 MGD MGI:2141032
Canis familiaris ALKBH2 VGNC VGNC:37803
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