2. Gene
  3. Btrc - beta-transducin repeat containing protein Gene

Btrc - beta-transducin repeat containing protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: HOS; FWD1; Fbw1a; Slimb; b-TrCP; beta-TrCP; Beta-Trcp1; SCF b-TRCP; E3RSIkappaB; E3RS-IkappaB

基因 ID: 12234 | 基因类型: protein coding

关于 Btrc

功能概要

Enables beta-catenin binding activity; protein phosphorylated amino acid binding activity; and ubiquitin protein Ligase activity. Involved in several processes, including cellular protein metabolic process; positive regulation of circadian rhythm; and regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including mammary gland epithelium development; protein K48-linked ubiquitination; and regulation of I-kappaB kinase/NF-kappaB signaling. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; peripheral nervous system; and respiratory system. Orthologous to human BTRC (beta-transducin repeat containing E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Btrc 基因产物(10)

mRNA Protein Name
NM_001037758.2 NP_001032847.2 F-box/WD repeat-containing protein 1A isoform a
NM_001286465.1 NP_001273394.1 F-box/WD repeat-containing protein 1A isoform a
NM_001286466.1 NP_001273395.1 F-box/WD repeat-containing protein 1A isoform c
NM_001360120.1 NP_001347049.1 F-box/WD repeat-containing protein 1A isoform d
NM_001360122.1 NP_001347051.1 F-box/WD repeat-containing protein 1A isoform e
NM_001360124.1 NP_001347053.1 F-box/WD repeat-containing protein 1A isoform f
NM_001360126.1 NP_001347055.1 F-box/WD repeat-containing protein 1A isoform g
NM_001360127.1 NP_001347056.1 F-box/WD repeat-containing protein 1A isoform h
NM_001409992.1 NP_001396921.1 F-box/WD repeat-containing protein 1A isoform f
NM_009771.3 NP_033901.1 F-box/WD repeat-containing protein 1A isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-catenin binding IDA
IDA: 通过直接分析推断
10228155 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16371461 MGI
enables protein phosphorylated amino acid binding IDA
IDA: 通过直接分析推断
10228155 MGI
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
10228155 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
32558204 MGI
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
21911472 MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: 通过突变表型推断
15340078 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: 通过直接分析推断
19103752 MGI
acts upstream of or within mammary gland epithelial cell proliferation IMP
IMP: 通过突变表型推断
15340078 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
18782782 MGI
involved in positive regulation of circadian rhythm IMP
IMP: 通过突变表型推断
18782782 MGI
acts upstream of or within protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
29593216 MGI
acts upstream of or within protein catabolic process IMP
IMP: 通过突变表型推断
12843402 MGI
involved in protein dephosphorylation IDA
IDA: 通过直接分析推断
18782782 MGI
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
10228155 MGI
acts upstream of or within protein ubiquitination IDA
IDA: 通过直接分析推断
32558204 MGI
acts upstream of or within regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
12843402 MGI
involved in regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
18929646 MGI
acts upstream of or within regulation of cell cycle IMP
IMP: 通过突变表型推断
12791266 MGI
acts upstream of or within regulation of proteasomal protein catabolic process IDA
IDA: 通过直接分析推断
19103752 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18929646 MGI
located in nucleus IDA
IDA: 通过直接分析推断
18929646 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

F-box/WD repeat-containing protein 1A

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99896 Runimotamab 99.00% Phase 1
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01680 BTRC Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20699 Btrc Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27210 Btrc Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Btrc NCBI NCBI:8945
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