NAA30 - N-alpha-acetyltransferase 30, NatC catalytic subunit Gene

中文名称：N-α-乙酰转移酶 30，NatC 催化亚基

种属: Homo sapiens

同用名: MAK3; Mak3p; NAT12; NAT12P; C14orf35

基因 ID: 122830 | 基因类型: protein coding

关于 NAA30

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:57,390,586-57,415,906 (from NCBI)

This gene has 4 transcripts (splice variants), 213 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 11.4), brain (RPKM 9.1) and 25 other tissues.

功能概要

启用肽α-N-乙酰转移酶活性。参与 N-末端肽基甲硫氨酸乙酰化。位于细胞质和细胞核中。 NatC 复合体的一部分。与多核糖体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal peptidyl-methionine acetylation. Located in cytosol and nucleus. Part of NatC complex. Colocalizes with polysome. [provided by Alliance of Genome Resources, Apr 2022]

NAA30 基因产物(1)

mRNA	Protein	Name
NM_001011713.3	NP_001011713.2	N-alpha-acetyltransferase 30

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables peptide alpha-N-acetyltransferase activity	IDA IDA: 通过直接分析推断	19398576	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19398576	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in protein stabilization	IDA IDA: 通过直接分析推断	37891180	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of NatC complex	IDA IDA: 通过直接分析推断	19398576	GOA
part of NatC complex	IPI IPI: 通过物理相互作用推断	19398576	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	19398576	GOA
located in nucleus	IDA IDA: 通过直接分析推断	25732826	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NAA30 蛋白结构

Acetyltransf_1

0
100
200
300
362 a.a.

蛋白主名

其他名称

N-alpha-acetyltransferase 30

N-acetyltransferase 12 (GCN5-related, putative)

NAA30 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NAA30	Q147X3	NAA35	Homo sapiens	Q5VZE5	Cosedimentation	19398576
种属内	NAA30	Q147X3	NAA35	Homo sapiens	Q5VZE5	Anti Tag CoIP	19398576
种属内	NAA30	Q147X3	NAA35	Homo sapiens	Q5VZE5	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Neurogenic Arthropathy

Neuropathic Arthropathy	Arthropathy Associated With Neurological Disorder
Charcot'S Arthropathy	Charcot'S Joint
Arthropathy, Neurogenic	Charcot Joint
Charcot Or Tabetic Arthropathy	Charcot Foot

Villonodular Synovitis

Pigmented Villonodular Synovitis

Ochronosis

Chondrocalcinosis

Pseudogout	Calcium Pyrophosphate Deposition Disease
Familial Chondrocalcinosis	Chondrocalcinosis Nos
Cppd - [Calcium Pyrophosphate Deposition Disease]	Cpdd - [Calcium Pyrophosphate Deposition Disease]
Chondrocalcinosis, Due To Pyrophosphate Crystals, Involving Unspecified Site	Chondrocalcinosis, Cause Unspecified
Chondrocalcinosis Due To Pyrophosphate Crystals	Chondrocalcinosis Articularis
Calcium Pyrophosphate Arthritis And Periarthritis

Microphthalmia, Syndromic 1

MCOPS1	Lenz Microphthalmia Syndrome
Lenz Dysplasia	Mcops4
Syndromic Microphthalmia 1	Lenz Microphthalmia
Maa	Microphthalmia Or Anophthalmos With Associated Anomalies
Syndromic Microphthalmia Type 4	Microphthalmia, Syndromic 4
Microphthalmia, Syndromic 4, Formerly	Mcops4, Formerly
Anop1, Formerly	Maa, Formerly
Lenz Type Microphthalmia	Syndromic Microphthalmia 4
Microphthalmia Lenz Type	Microphthalmia Syndromic 1
Syndromic Microphthalmia Type 1	Microphthalmia Syndromic 4
Microphthalmia With Ankyloblepharon And Intellectual Disability	Microphthalmia, Lenz Type
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome	Microphthalmia, Syndromic, 1
Anop1	Microphthalmia, Syndromic, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08989	NAA30 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	NAA30	MGD	MGI:1922259
Bos taurus	NAA30	VGNC	VGNC:54627
Rattus norvegicus	NAA30	RGD	RGD:1559923
Canis familiaris	NAA30	VGNC	VGNC:50549
Macaca mulatta	NAA30	VGNC	VGNC:84405
Felis catus	NAA30	VGNC	VGNC:80907

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