2. Gene
  3. Ccne1 - cyclin E1 Gene

Ccne1 - cyclin E1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CycE1

基因 ID: 12447 | 基因类型: protein coding

关于 Ccne1

功能概要

Enables cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; and protein kinase binding activity. Acts upstream of or within several processes, including DNA metabolic process; homologous chromosome pairing at meiosis; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of cyclin E1-CDK2 complex. Is expressed in several structures, including brain; early conceptus; embryo ectoderm; eye; and spinal cord. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human CCNE1 (cyclin E1). [provided by Alliance of Genome Resources, Apr 2022]

Ccne1 基因产物(1)

mRNA Protein Name
NM_007633.2 NP_031659.2 G1/S-specific cyclin-E1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
IDA: 通过直接分析推断
12970171 MGI
enables kinase activity IDA
IDA: 通过直接分析推断
12124778 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10500095 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
11981756 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA replication initiation IMP
IMP: 通过突变表型推断
12941272 MGI
acts upstream of or within Wnt signaling pathway IDA
IDA: 通过直接分析推断
19056892 MGI
acts upstream of or within chromosome organization involved in meiotic cell cycle IGI
IGI: 通过遗传相互作用推断
24586195 MGI
acts upstream of or within homologous chromosome pairing at meiosis IGI
IGI: 通过遗传相互作用推断
24586195 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
7797074 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
12124778 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: 通过直接分析推断
12970171 MGI
acts upstream of or within regulation of protein localization IGI
IGI: 通过遗传相互作用推断
24586195 MGI
acts upstream of or within telomere maintenance IGI
IGI: 通过遗传相互作用推断
24586195 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cyclin E1-CDK2 complex IDA
IDA: 通过直接分析推断
7739547 MGI
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: 通过物理相互作用推断
12970760 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10500095 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

G1/S-specific cyclin-E1

Ccne1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Ccne1 Q61457 Cdk1 Mus musculus P11440
Anti Bait CoIP
19592082
种属内
Ccne1 Q61457 Cdk2 Mus musculus P97377
Anti Bait CoIP
20150892
种属内
Ccne1 Q61457 Cdk2 Mus musculus P97377
Anti Bait CoIP
19592082
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Ccne1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72964 Cyclin E Protein, Mouse (sf9, His-GST) Q61457 (M1-E408) ≥95%

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-145817A lunresertib Inhibitor 99.97% Phase 2
HY-160701 Cirtociclib 99.02% Phase 2
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-162255 CDK2-IN-23 Inhibitor 99.22% 否
HY-RS02127 CCNE1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-161463 CDK2-IN-28 Inhibitor / 否
HY-RS17273 Ccne1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23727 Ccne1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ccne1 NCBI NCBI:898
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