2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK2 degrader 7

CDK2 degrader 7 是一种口服活性的 CDK2 降解剂，在 MKN1 细胞和 TOV21G 细胞中的 DC50 值分别为 13 nM 和 17 nM。CDK2 degrader 7 可诱导 MKN1 细胞的 G1 期阻滞。CDK2 degrader 7 在 HCC1569 (CCNE1 扩增) 异种移植模型中实现肿瘤抑制。CDK2 degrader 7 可用于 CCNE1 扩增型癌症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

CDK2 degrader 7

CDK2 degrader 7 Chemical Structure

CAS No. : 3030279-55-8

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

CDK2 degrader 7 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK2 degrader 7 is an orally active CDK2 degrader, with DC50 values of 13 nM (MKN1cells) and 17 nM (TOV21G cells). CDK2 degrader 7 induces G1 phase arrest in MKN1 cells. CDK2 degrader 7 achieves tumor stasis in HCC1569 (CCNE1-amplified) xenograft models. CDK2 degrader 7 can be used for the study of CCNE1-amplified cancers[1].

IC50 & Target[1]

CDK2

13 nM (DC50, MKN1cells)

CDK2

17 nM (DC50, TOV21G cells)

CDK1

2130 nM (DC50)

体外研究
(In Vitro)

CDK2 degrader 7 (Compound 37) 在 MKN1 (CCNE1 扩增) 和 TOV21G (CCNE1 非扩增) 细胞中表现出强效的 CDK2 降解活性，DC50 值分别为 13 nM 和 17 nM[1]。
CDK2 degrader 7 对 MKN1 (CCNE1 扩增) 细胞表现出强效的抗增殖活性，IC50 为 9 nM，而对 TOV21G (CCNE1 非扩增) 细胞的活性较弱，IC50 为 5760 nM[1]。
CDK2 degrader 7 (4.88-5000 nM, 72 h) 在 MKN1 细胞中在 78 nM 时诱导最大 G1 期阻滞 (靶向作用)，在 2500 nM 时出现非靶向的 G2/M 期积累[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK2 degrader 7 相关抗体:
体内研究
(In Vivo)

CDK2 degrader 7 (Compound 37) (10-50 mg/kg, 口服, 每日一次或两次, 28 天) 在 HCC1569 (CCNE1 扩增) 异种移植模型中表现出强效的抗肿瘤活性\[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCC1569 human breast carcinoma cells (6 × 106 cells + Matrigel in 0.2 mL RPMI 1640 medium) were subcutaneously implanted into the central right flank of 7-day acclimated female NOG mice[1]
Dosage: 10 mg/kg, 25 mg/kg, 50 mg/kg
Administration: p.o., once or twice daily, 28 days
Result: Achieved tumor stasis in HCC1569 (CCNE1-amplified) xenograft model.
分子量

852.89

Formula

C39H46F6N8O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK2 degrader 7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2 degrader 73030279-55-8CDKCyclin dependent kinaseMKN1 cellsTOV21G cellscancerHCC1569Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CDK2 degrader 7
目录号：
HY-175842
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z