1. Gene
  2. CNR2 - cannabinoid receptor 2 Gene

CNR2 - cannabinoid receptor 2 Gene

中文名称:大麻素受体 2

种属: Homo sapiens

同用名: CB2; CX5; CB-2

基因 ID: 1269 | 基因类型: protein coding

关于 CNR2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:23,870,515-23,913,362 (from NCBI)

This gene has 1 transcript (splice variant), 196 orthologues and 18 paralogues. Biased expression in lymph node (RPKM 3.7), spleen (RPKM 3.4) and 4 other tissues.

功能概要

大麻素 delta-9-四氢大麻酚是大麻的主要精神活性成分。由该基因和大麻素受体 1 (脑) (CNR1) 基因编码的蛋白质具有大麻素鸟嘌呤核苷酸结合蛋白 (G 蛋白) 偶联受体的特征。它们以剂量依赖性、立体选择性和百日咳毒素敏感方式抑制腺苷酸环化酶活性。已发现这些蛋白质参与了大麻使用者所经历的大麻素诱导的中枢神经系统效应 (包括情绪和认知的改变) 。大麻素受体是 G 蛋白偶联受体家族 1 的成员。[RefSeq 提供,2008 年 7 月]

The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the Cannabinoid Receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit Adenylate Cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]

CNR2 基因产物(4)

mRNA Protein Name
XM_047444833.1 XP_047300789.1 cannabinoid receptor 2 isoform X1
XM_017000261.3 XP_016855750.1 cannabinoid receptor 2 isoform X1
NM_001841.3 NP_001832.1 cannabinoid receptor 2
XM_011540629.4 XP_011538931.1 cannabinoid receptor 2 isoform X1

CNR2 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (50 - 299)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
蛋白主名 其他名称

cannabinoid receptor 2

cannabinoid receptor 2 (macrophage)

重组 CNR2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700636 CNR2 Protein-VLP, Human (HEK293) P34972 (M1-C360) ≥95%

关联疾病

疾病名称 别名
Chlorhexidine Allergy
Purulent Labyrinthitis

Suppurative Labyrinthitis

Acute Suppurative Labyrinthitis

Bacterial Labyrinthitis

Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis

Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus CNR2 VGNC VGNC:27530
Canis familiaris CNR2 VGNC VGNC:39427
Mus musculus CNR2 MGD MGI:104650
Felis catus CNR2 VGNC VGNC:80173
Macaca mulatta CNR2 VGNC VGNC:71281
Rattus norvegicus CNR2 RGD RGD:619713
Others CNR2 NCBI