2. Gene
  3. Col1a1 - collagen, type I, alpha 1 Gene

Col1a1 - collagen, type I, alpha 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Cola1; Mov13; Cola-1; Mov-13; Col1a-1

基因 ID: 12842 | 基因类型: protein coding

关于 Col1a1

功能概要

This gene encodes the alpha-1 subunit of the fibril-forming type I Collagen, the most abundant protein of bone, skin and tendon extracellular matrices. The encoded protein, in association with alpha-2 subunit, forms heterotrimeric type I procollagen that undergoes proteolytic processing during fibril formation. Mice lacking the encoded protein die in utero caused by the rupture of a major blood vessel. Transgenic mice expressing significantly lower levels of this gene exhibit morphological and functional defects in mineralized and non-mineralized connective tissue and, progressive loss of hearing. [provided by RefSeq, Nov 2015]

Col1a1 基因产物(1)

mRNA Protein Name
NM_007742.4 NP_031768.2 collagen alpha-1(I) chain preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables extracellular matrix structural constituent IDA
IDA: 通过直接分析推断
15383546 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
9213002 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
7629088 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within blood vessel development IMP
IMP: 通过突变表型推断
14630726 MGI
acts upstream of or within bone trabecula formation IGI
IGI: 通过遗传相互作用推断
17440987 MGI
acts upstream of or within cartilage development involved in endochondral bone morphogenesis IMP
IMP: 通过突变表型推断
18248096 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: 通过直接分析推断
20548288 MGI
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
21625049 MGI
acts upstream of or within endochondral ossification IMP
IMP: 通过突变表型推断
8130375 MGI
acts upstream of or within face morphogenesis IGI
IGI: 通过遗传相互作用推断
17440987 MGI
acts upstream of or within intramembranous ossification IGI
IGI: 通过遗传相互作用推断
17440987 MGI
acts upstream of or within negative regulation of cell-substrate adhesion IDA
IDA: 通过直接分析推断
17018525 MGI
involved in osteoblast differentiation IEP
IEP: 通过表达模式推断
16311053 MGI
acts upstream of or within protein transport IMP
IMP: 通过突变表型推断
8906420 MGI
acts upstream of or within skeletal system development IMP
IMP: 通过突变表型推断
8163675 MGI
acts upstream of or within skeletal system morphogenesis IGI
IGI: 通过遗传相互作用推断
17440987 MGI
acts upstream of or within skin development IMP
IMP: 通过突变表型推断
18248096 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of collagen trimer IDA
IDA: 通过直接分析推断
7704020 MGI
part of collagen trimer IMP
IMP: 通过突变表型推断
14630726 MGI
part of collagen type I trimer IDA
IDA: 通过直接分析推断
8018053 MGI
part of collagen type I trimer IMP
IMP: 通过突变表型推断
7790374 MGI
located in collagen-containing extracellular matrix IDA
IDA: 通过直接分析推断
34368841 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
8018053 MGI
located in extracellular matrix IDA
IDA: 通过直接分析推断
2209468 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
34368841 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

collagen alpha-1(I) chain

alpha-1 type 1 collagen

alpha-1 type I collagen

procollagen, type I, alpha 1

相关产品

Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-47888 PLN-1474 Inhibitor 99.35% 否
HY-120006A (rel)-AR234960 Agonist 98.95% 否
HY-151932 FXR agonist 3 Agonist 95.94% 否
HY-146434 TGFβ-IN-2 Inhibitor 99.37% 否
HY-147195 QH536 Inhibitor / 否
HY-154979 Anti-hepatic fibrosis agent 2 / 否
HY-155328 GK444 Inhibitor / 否
HY-172258 5-HT2B antagonist-2 Inhibitor / 否
HY-176737 TGF-β1/Smad-IN-1 Inhibitor / 否
HY-RS02970 COL1A1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS16961 Col1a1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS23404 Col1a1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Col1a1 NCBI NCBI:1277
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