2. Metabolic Enzyme/Protease
  3. HMG-CoA Reductase (HMGCR)
  4. QH536

QH536 (Compound 29) 是一种有效的 HMGCR 降解剂，EC50 为 0.22 μM。QH536 无诱导胆固醇在细胞内积聚的副作用。QH536 具有抗炎作用，可用于心血管疾病和非酒精性脂肪性肝炎的研究。

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QH536 Chemical Structure

QH536 Chemical Structure

CAS No. : 2754254-07-2

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QH536 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

QH536 (Compound 29) is a potent HMGCR degrader with an EC50 of 0.22 μM. QH536 has no side-effect of inducing cholesterol accumulation in cells. QH536 shows anti-inflammatory and can be used for cardiovascular disease and nonalcoholic steatohepatitis research[1].

IC50 & Target

IC50: 0.22 μM (HMGCR)[1]
分子量

535.76

Formula

C33H49N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

QH536 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QH5362754254-07-2QH 536QH-536HMG-CoA Reductase (HMGCR)LX-2cholesterolRAW264.7NASHnonalcoholic steatohepatitisα-SMACOL1A1TIMP1TGFb1TNF-aIL-6IL-1bCVDcardiovascular diseaseInhibitorinhibitorinhibit

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目录号：
HY-147195
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