2. Gene
  3. TSHZ2 - teashirt zinc finger homeobox 2 Gene

TSHZ2 - teashirt zinc finger homeobox 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：teashirt 锌指同源盒 2

种属: Homo sapiens

同用名: TSH2; ZABC2; ZNF218; OVC10-2; C20orf17

基因 ID: 128553 | 基因类型: protein coding

关于 TSHZ2

Cytogenetic location: 20q13.2 Genomic coordinates (GRCh38): 20:52,972,358-53,495,330 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in gall bladder (RPKM 3.9), ovary (RPKM 3.7) and 23 other tissues.

功能概要

该基因是 teashirt C2H2 型锌指蛋白转录因子家族的成员。该基因编码的蛋白质具有五个 C2H2 型锌指、一个同源盒 DNA 结合结构域和一个卷曲螺旋结构域。预计该核蛋白将充当转录抑制因子。该基因被认为在乳腺癌和其他类型癌症的发生和发展中发挥作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 12 月]

This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of Cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

TSHZ2 基因产物(2)

mRNA Protein Name
NM_001193421.2 NP_001180350.1 teashirt homolog 2 isoform 2
NM_173485.6 NP_775756.3 teashirt homolog 2 isoform 1

TSHZ2 蛋白结构

zf-C2H2_2

zf-C2H2_2: C2H2 type zinc-finger (2 copies) (266 - 301)

zf-C2H2_2

zf-C2H2_2: C2H2 type zinc-finger (2 copies) (380 - 407)

zf-C2H2_2

zf-C2H2_2: C2H2 type zinc-finger (2 copies) (928 - 1023)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1034 a.a.
蛋白主名 其他名称

teashirt homolog 2

cell growth-inhibiting protein 7

关联疾病

疾病名称 别名
Autosomal Recessive Alport Syndrome

Alport Syndrome, Recessive Type

Alport Syndrome, Autosomal Recessive

Alport Syndrome Autosomal Recessive

Alport Syndrome Recessive Type

Nephropathy And Deafness
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15149 TSHZ2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TSHZ2 VGNC VGNC:47904
Mus musculus TSHZ2 MGD MGI:2153084
Rattus norvegicus TSHZ2 RGD RGD:6490867
Macaca mulatta TSHZ2 VGNC VGNC:78875
Bos taurus TSHZ2 VGNC VGNC:59371
Felis catus TSHZ2 VGNC VGNC:66618
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