TANGO2 - transport and golgi organization 2 homolog Gene

中文名称：运输和高尔基体组织 2 同系物

种属: Homo sapiens

同用名: MECRCN; C22orf25

基因 ID: 128989 | 基因类型: protein coding

关于 TANGO2

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,017,023-20,067,164 (from NCBI)

This gene has 26 transcripts (splice variants), 211 orthologues and is associated with 3 phenotypes. Ubiquitous expression in heart (RPKM 11.7), bone marrow (RPKM 9.2) and 25 other tissues.

功能概要

该基因属于运输和高尔基体组织家族，其成员预计在内质网中的分泌蛋白装载中发挥作用。果蝇 S2 细胞中该基因的耗尽导致高尔基体与 ER 融合。在小鼠组织培养细胞中，该蛋白与线粒体靶向的 mCherry 蛋白共定位，并显示与高尔基体和过氧化物酶体的共定位水平非常低。该基因的等位基因变异与横纹肌溶解症、脑病代谢危象和心律失常有关。[RefSeq 提供，2016 年 4 月]

This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low levels of co-localization with Golgi and peroxisomes. Allelic variants of this gene are associated with rhabdomyolysis, metabolic crises with encephalopathy, and cardiac arrhythmia. [provided by RefSeq, Apr 2016]

TANGO2 基因产物(34)

mRNA	Protein	Name
NM_001283106.3	NP_001270035.1	transport and Golgi organization protein 2 homolog isoform a
NM_001283116.3	NP_001270045.1	transport and Golgi organization protein 2 homolog isoform a
NM_001283129.3	NP_001270058.1	transport and Golgi organization protein 2 homolog isoform b
NM_001283148.3	NP_001270077.1	transport and Golgi organization protein 2 homolog isoform c
NM_001283154.3	NP_001270083.1	transport and Golgi organization protein 2 homolog isoform c
NM_001283179.3	NP_001270108.1	transport and Golgi organization protein 2 homolog isoform d
NM_001283186.3	NP_001270115.1	transport and Golgi organization protein 2 homolog isoform d
NM_001283199.3	NP_001270128.1	transport and Golgi organization protein 2 homolog isoform e
NM_001283215.3	NP_001270144.1	transport and Golgi organization protein 2 homolog isoform f
NM_001283235.3	NP_001270164.1	transport and Golgi organization protein 2 homolog isoform g
NM_001283248.3	NP_001270177.1	transport and Golgi organization protein 2 homolog isoform h
NM_001322141.2	NP_001309070.1	transport and Golgi organization protein 2 homolog isoform i
NM_001322142.2	NP_001309071.1	transport and Golgi organization protein 2 homolog isoform j
NM_001322143.2	NP_001309072.1	transport and Golgi organization protein 2 homolog isoform b
NM_001322144.2	NP_001309073.1	transport and Golgi organization protein 2 homolog isoform l
NM_001322145.2	NP_001309074.1	transport and Golgi organization protein 2 homolog isoform m
NM_001322146.2	NP_001309075.1	transport and Golgi organization protein 2 homolog isoform k
NM_001322147.2	NP_001309076.1	transport and Golgi organization protein 2 homolog isoform m
NM_001322148.2	NP_001309077.1	transport and Golgi organization protein 2 homolog isoform n
NM_001322149.2	NP_001309078.1	transport and Golgi organization protein 2 homolog isoform r
NM_001322150.2	NP_001309079.1	transport and Golgi organization protein 2 homolog isoform o
NM_001322153.2	NP_001309082.1	transport and Golgi organization protein 2 homolog isoform o
NM_001322155.2	NP_001309084.1	transport and Golgi organization protein 2 homolog isoform o
NM_001322160.2	NP_001309089.1	transport and Golgi organization protein 2 homolog isoform p
NM_001322163.2	NP_001309092.1	transport and Golgi organization protein 2 homolog isoform d
NM_001322166.2	NP_001309095.1	transport and Golgi organization protein 2 homolog isoform d
NM_001322167.2	NP_001309096.1	transport and Golgi organization protein 2 homolog isoform d
NM_001322169.2	NP_001309098.1	transport and Golgi organization protein 2 homolog isoform q
NM_001322171.2	NP_001309100.1	transport and Golgi organization protein 2 homolog isoform g
NM_001322172.2	NP_001309101.1	transport and Golgi organization protein 2 homolog isoform g
NM_001322173.2	NP_001309102.1	transport and Golgi organization protein 2 homolog isoform g
NM_001322174.2	NP_001309103.1	transport and Golgi organization protein 2 homolog isoform g
NM_001322175.2	NP_001309104.1	transport and Golgi organization protein 2 homolog isoform g
NM_152906.7	NP_690870.3	transport and Golgi organization protein 2 homolog isoform a

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	26805781	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	31276219	GOA
located in cytosol	IDA IDA: 通过直接分析推断	32909282	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	32909282	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

transport and Golgi organization protein 2 homolog

TANGO2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TANGO2	Q6ICL3	SH3GL2	Homo sapiens	Q99962	Anti Tag CoIP	33961781
种属内	TANGO2	Q6ICL3	SH3GL2	Homo sapiens	Q99962	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration

Metabolic Encephalomyopathic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration	MECRCN
Rhabdomyolysis

Tango2-Related Metabolic Encephalopathy And Arrhythmias

Recurrent Metabolic Encephalomyopathic Crises-Rhabdomyolysis-Cardiac Arrhythmia-Intellectual Disability Syndrome	Tango2
Metabolic Encephalomyopathic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration	Tango2 Related Disease
Tango2-Related Metabolic Encephalopathy-Arrhythmia Syndrome	Tango2-Related Disorder

Episodic Ataxia

Isaacs Syndrome	Neuromyotonia
Isaacs' Syndrome	Acquired Neuromyotonia
Continuous Muscle Fiber Activity Syndrome	Quantal Squander Syndrome
Isaacs-Mertens Syndrome	Ea Syndrome
Episodic Ataxia Syndrome	Isaac Syndrome
Isaac'S-Merten'S Syndrome	Isaac-Mertens Syndrome
Peripheral Nerve Hyperexcitability	Ea
Peripheral Nerve Hyperexcitability Syndrome	Ataxia, Episodic
Isaacs Neuromyotonia	Continuous Muscle Fibre Activity

Hereditary Episodic Ataxia

Pitt-Hopkins-Like Syndrome 2

PTHSL2	Mesh
D006985	Mesh
D008607

Treacher Collins Syndrome 3

TCS3	Mandibulofacial Dysostosis, Treacher Collins Type, Autosomal Recessive
Mandibulofacial Dysostosis Treacher Collins Type Autosomal Recessive

Lissencephaly 6

Lis6

Ectodermal Dysplasia 14, Hair/Tooth Type With Or Without Hypohidrosis

ECTD14	Ectodermal Dysplasia 14
Ectn14

Leukodystrophy, Hypomyelinating, 11

Hypomyelinating Leukodystrophy 11	HLD11
4h Leukodystrophy 3	Leukodystrophy, Hypomyelinating, Type 11

Chromosome 6q24-Q25 Deletion Syndrome

Chromosome 6q25-Q25 Deletion Syndrome	6q25 Microdeletion Syndrome
Monosomy 6q25	Del(6)(Q25)

Alternating Hemiplegia Of Childhood

Alternating Hemiplegia	Ahc
Alternating Hemiplegia Syndrome	Hemiplegia, Alternating, Of Childhood
Hemiplegia, Crossed

Velocardiofacial Syndrome

Shprintzen Syndrome	VCFS
Chromosome 22q11.2 Deletion Syndrome	Vcf Syndrome
Shprintzen Vcf Syndrome	Vcf-Velocardiofacial Syndrome
Velo-Cardio-Facial Syndrome	Digeorge Syndrome
22q11 Deletion Syndrome	Conotruncal Anomaly Face Syndrome

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14196	TANGO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	TANGO2	RGD	RGD:1310348
Canis familiaris	TANGO2	VGNC	VGNC:52971
Felis catus	TANGO2	VGNC	VGNC:65950
Mus musculus	TANGO2	MGD	MGI:101825
Bos taurus	TANGO2	VGNC	VGNC:106964
Macaca mulatta	TANGO2	VGNC	VGNC:78209

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TANGO2 - transport and golgi organization 2 homolog Gene

关于 TANGO2

功能概要

TANGO2 基因产物(34)

TANGO2 蛋白互作信息

关联疾病

直系同源

热门区域

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TANGO2 - transport and golgi organization 2 homolog Gene

关于 TANGO2

功能概要

TANGO2 基因产物(34)

TANGO2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z