2. Gene
  3. Crx - cone-rod homeobox Gene

Crx - cone-rod homeobox Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Crx1

基因 ID: 12951 | 基因类型: protein coding

关于 Crx

功能概要

Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and nuclear receptor binding activity. Involved in regulation of transcription, DNA-templated. Acts upstream of or within positive regulation of transcription by RNA polymerase II and retina development in camera-type eye. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including eye; face; and nervous system. Used to study Leber congenital amaurosis 7. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 7 and cone-rod dystrophy 2. Orthologous to human CRX (cone-rod homeobox). [provided by Alliance of Genome Resources, Apr 2022]

Crx 基因产物(2)

mRNA Protein Name
NM_001113330.1 NP_001106801.1 cone-rod homeobox protein isoform 2
NM_007770.4 NP_031796.1 cone-rod homeobox protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
15689355 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
20026326 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
14613968 MGI
enables nuclear receptor binding IPI
IPI: 通过物理相互作用推断
16574740 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14613968 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12407160 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
12407160 MGI
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16574740 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: 通过突变表型推断
21052544 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
15689355 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
15689355 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cone-rod homeobox protein

cone-rod homeobox containing

Crx 抗体

目录号 产品名 应用 反应物种
HY-P86825 CRX Antibody (YA6518) WB, IHC-P Mouse, Rat

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-111792 GSK1795091 Agonist 94.48% Phase 1
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153759 CRX000227 Modulator 95.0% 否
HY-155801 CRX 527 Ligand / 否
HY-RS03203 CRX Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-118984 CRX-526 Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Crx NCBI NCBI:1406
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