2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. GSK1795091

GSK1795091  (Synonyms: CRX-601)

目录号: HY-111792
产品使用指南

摩尔计算器

GSK1795091，一种免疫刺激剂，是一种合成的 TLR4 激动剂。具有抗肿瘤活性。GSK1795091 可用作疫苗佐剂，以增强对流感病毒疫苗的粘膜和全身免疫力。GSK1795091 不仅抑制小鼠模型中的肿瘤发展，提供存活率，还导致小鼠流感模型长期存活。

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GSK1795091 Chemical Structure

GSK1795091 Chemical Structure

CAS No. : 1233589-81-5

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规格 价格 是否有货 数量
1 mg ￥12744
16 - 18 周
5 mg ￥25552
16 - 18 周
10 mg ￥40600
16 - 18 周
50 mg   询价  
100 mg   询价  

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Customer Review

GSK1795091 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK1795091 (CRX-601), an immunologic stimulator, is a synthetic TLR4 agonist. Antitumor activity. GSK1795091 can be used as a vaccine adjuvant to enhance both mucosal and systemic immunity to influenza virus vaccines. Not only, GSK1795091 inhibits tumor growth and increases the survival in mice model, but results in long term survival in influenza challenge model in mice[1][2][3].

体内研究
(In Vivo)

GSK1795091 (CRX-601) (0.1 μg /鼠，鼻腔给药) 作为佐剂结合流感抗原 (H3N2) 诱导小鼠强烈的粘膜和全身免疫应答[1]。
GSK1795091 (25 μg/mouse；静脉注射；每周一次，共 3 次) 抑制肿瘤生长，并导致小鼠肿瘤模型中的长期存活[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice primed with H3N2[1]
Dosage: 0.1 μg /mouse
Administration: Intranasal administration
Result: As an adjuvant combined with detergent split-influenza antigen (H3N2) generated strong local and systemic immunity against co-administered influenza antigens while exhibiting high efficacy against two heterotypic influenza challenges.
Mice receiving adjuvanted vaccines had significantly higher IgA titers than non-adjuvanted (vehicle) controls in an adjuvant dose-dependent manner.
Adjuvanted vaccines promoted antigen-specific IgG and IgA antibody responses and the generation of polyfunctional antigen-specific Th17 cells.
Clinical Trial
分子量

1446.09

Formula

C81H157N2O16P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK1795091 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK17950911233589-81-5CRX-601GSK 1795091GSK-1795091CRX601CRX 601Toll-like Receptor (TLR)immunologic stimulatorantitumorvaccine adjuvantvirusInhibitorinhibitorinhibit

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