1. Gene
  2. KCNH8 - potassium voltage-gated channel subfamily H member 8 Gene

KCNH8 - potassium voltage-gated channel subfamily H member 8 Gene

中文名称:钾电压门控通道亚家族 H 成员 8

种属: Homo sapiens

同用名: ELK; ELK1; elk3; Kv12.1

基因 ID: 131096 | 基因类型: protein coding

关于 KCNH8

Cytogenetic location: 3p24.3 Genomic coordinates (GRCh38): 3:19,148,510-19,535,642 (from NCBI)

This gene has 3 transcripts (splice variants), 221 orthologues and 17 paralogues. Biased expression in brain (RPKM 4.2), adrenal (RPKM 1.5) and 13 other tissues.

功能概要

从功能和结构的角度来看,电压门控钾 (Kv) 通道代表了最复杂的一类电压门控离子通道。它们的不同功能包括调节神经递质释放、心率、胰岛素分泌、神经元兴奋性、上皮电解质转运、平滑肌收缩和细胞体积。该基因编码钾通道电压门控 H 亚科的一个成员。该成员是一个成孔 (alpha) 亚基。[RefSeq 提供,2008 年 7 月]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the Potassium Channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. [provided by RefSeq, Jul 2008]

KCNH8 基因产物(1)

mRNA Protein Name
NM_144633.3 NP_653234.2 potassium voltage-gated channel subfamily H member 8
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables delayed rectifier potassium channel activity IDA
IDA: 通过直接分析推断
11897058 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in potassium ion transport IDA
IDA: 通过直接分析推断
11897058 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

KCNH8 蛋白结构

PAS_9

PAS_9: PAS domain (40 - 135)

Ion_trans

Ion_trans: Ion transport protein (261 - 469)

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (572 - 656)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1107 a.a.
蛋白主名 其他名称

potassium voltage-gated channel subfamily H member 8

ELK channel 3

直系同源

种属 基因名 来源 基因 ID
Bos taurus KCNH8 VGNC VGNC:55057
Macaca mulatta KCNH8 VGNC VGNC:73855
Felis catus KCNH8 VGNC VGNC:63039
Canis familiaris KCNH8 VGNC VGNC:42253
Rattus norvegicus KCNH8 RGD RGD:2549
Mus musculus KCNH8 MGD MGI:2445160