Dbh - dopamine beta hydroxylase Gene

中文名称：多巴胺 β 羟化酶

种属: Mus musculus

关于 Dbh

功能概要

预计该基因编码的蛋白可启动铜离子结合活性和多巴胺 β-单加氧酶活性。参与儿茶酚胺代谢过程；运动行为；和冷诱导产热的正调节。在几个过程的上游或内部起作用，包括对乙醇的行为反应；恒温;和学习或记忆。位于分泌颗粒腔和分泌颗粒膜内。以多种结构表达，包括肾上腺；消化系统；和神经系统。用于研究多巴胺 β-羟化酶缺乏症。该基因的人类直系同源基因与多种疾病有关，包括酒精使用障碍；注意力缺陷多动障碍;多巴胺β-羟化酶缺乏症；高血压;和有先兆的偏头痛。与人类 DBH（多巴胺 β-羟化酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Involved in Catecholamine metabolic process; locomotory behavior; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including behavioral response to ethanol; homoiothermy; and learning or memory. Located in secretory granule lumen and secretory granule membrane. Is expressed in several structures, including adrenal gland; alimentary system; and nervous system. Used to study dopamine beta-hydroxylase deficiency. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]