2. Gene
  3. Dcc - deleted in colorectal carcinoma Gene

Dcc - deleted in colorectal carcinoma Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Igdcc1; C030036D22Rik

基因 ID: 13176 | 基因类型: protein coding

关于 Dcc

功能概要

Predicted to enable identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within generation of neurons. Located in axon. Is integral component of postsynaptic density membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and retina. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; esophageal cancer; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Dcc 基因产物(1)

mRNA Protein Name
NM_007831.3 NP_031857.2 netrin receptor DCC precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11527412 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within anterior/posterior axon guidance IMP
IMP: 通过突变表型推断
18479186 MGI
acts upstream of or within dorsal/ventral axon guidance IMP
IMP: 通过突变表型推断
17898206 MGI
acts upstream of or within neuron migration IMP
IMP: 通过突变表型推断
16267219 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
23291093 MGI
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
23291093 MGI
acts upstream of or within spinal cord ventral commissure morphogenesis IMP
IMP: 通过突变表型推断
9126737 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
23291093 MGI
is active in Schaffer collateral - CA1 synapse IEP
IEP: 通过表达模式推断
23291093 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
23291093 MGI
located in axon IDA
IDA: 通过直接分析推断
9331350 MGI
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
23291093 MGI
is active in postsynaptic density membrane IEP
IEP: 通过表达模式推断
23291093 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

netrin receptor DCC

tumor suppressor protein DCC

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-112306 Ripretinib 98.90% 是
HY-136256 Vimseltinib Inhibitor 99.94% 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-13024 Rebastinib 99.91% Phase 2
HY-160699 DCC-3116 Inhibitor 99.25% Phase 2
HY-B0791 Altiratinib Inhibitor 99.29% Phase 1
Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-Y1092 N,N-Dicyclohexylcarbodiimide(DCC) Activator 99.75% 否
HY-W074890 Palmitoylglycine Modulator 99.74% 否
HY-100855 DC_C66 Inhibitor / 否
HY-157262 Methyl isonicotinate-(CH2)2-COOH / 否
HY-163008 Dicamba-5-aminopentanoic acid / 否
HY-RS03571 DCC Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-D2751 BP Fluor 488 cadaverine / 否
HY-D2764 Difluorocarboxyfluorescein cadaverine, 5-isomer / 否
HY-D2765 BP Fluor 405 cadaverine / 否
HY-D2772 5-TAMRA Cadaverine / 否
HY-RS17183 Dcc Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23634 Dcc Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dcc NCBI NCBI:1630
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