2. Epigenetics
  3. Histone Methyltransferase
  4. DC_C66

DC_C66 是一种细胞渗透性的，选择性的 (CARM1) 抑制剂，IC50 值为 1.8 μM。DC_C66 相对 PRMT1 (IC50=21 μM)，PRMT6 (IC50= 47μM)，PRMT5，具有良好的选择性。

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DC_C66 Chemical Structure

DC_C66 Chemical Structure

CAS No. : 108181-00-6

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DC_C66 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC50=21 μM), PRMT6 (IC50= 47μM), and PRMT5[1].

IC50 & Target

IC50: 1.8 μM (CARM1)[1]
体外研究
(In Vitro)

DC_C66 (6.25-100 μM; 24-72 hours) exhibits antiproliferation activity in several CARM1-associated cancer cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DC_C66 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HELA, K562, MCF7 cells
Concentration: 6.25, 12.5, 25, 50, 100 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibits proliferation of cancer cells in a time-dependent and dose-dependent manner in HELA, K562, and MCF7 cells.
分子量

404.48

Formula

C28H22NO2+
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DC_C66 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DC_C66108181-00-6Histone MethyltransferaseInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-100855
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