2. Gene
  3. ADK - adenosine kinase Gene

ADK - adenosine kinase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：腺苷激酶

种属: Homo sapiens

同用名: AK

基因 ID: 132 | 基因类型: protein coding

关于 ADK

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:74,151,221-74,709,290 (from NCBI)

This gene has 14 transcripts (splice variants), 275 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in liver (RPKM 10.9), thyroid (RPKM 8.6) and 25 other tissues.

功能概要

该基因是一种催化 γ-磷酸从 ATP 转移到腺苷的酶，从而充当细胞外腺苷和细胞内腺嘌呤核苷酸浓度的调节剂。腺苷对心血管、神经、呼吸系统和免疫系统具有广泛的影响，酶的抑制剂可以在增加血管内腺苷浓度和作为抗炎剂方面发挥重要的药理学作用。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 1 月]

This gene an Enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the Enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

ADK 基因产物(15)

mRNA Protein Name
NM_001369123.1 NP_001356052.1 adenosine kinase isoform e
XM_017015703.3 XP_016871192.1 adenosine kinase isoform X5
XM_017015706.2 XP_016871195.1 adenosine kinase isoform X8
NM_001123.4 NP_001114.2 adenosine kinase isoform a
XM_017015699.2 XP_016871188.1 adenosine kinase isoform X3
NM_001202449.2 NP_001189378.1 adenosine kinase isoform c
NM_001202450.2 NP_001189379.1 adenosine kinase isoform d
XM_017015698.2 XP_016871187.1 adenosine kinase isoform X1
NM_006721.4 NP_006712.2 adenosine kinase isoform b
XM_047424621.1 XP_047280577.1 adenosine kinase isoform X9
XM_017015705.2 XP_016871194.1 adenosine kinase isoform X7
XM_017015704.2 XP_016871193.1 adenosine kinase isoform X6
XM_017015702.2 XP_016871191.1 adenosine kinase isoform X4
XM_047424620.1 XP_047280576.1 adenosine kinase isoform X2
NM_001369124.1 NP_001356053.1 adenosine kinase isoform f

ADK 蛋白结构

PfkB

PfkB: pfkB family carbohydrate kinase (44 - 356)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
蛋白主名 其他名称

adenosine kinase

adenosine 5'-phosphotransferase

testicular tissue protein Li 14

重组 ADK 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75529 ADK/Adenosine Kinase Protein, Human (sf9, His-GST) AAH03568 (M1-H345) ≥95%
HY-P75530 ADK/Adenosine Kinase Protein, Human (HEK293) AAH03568 (M1-H345) ≥95%

关联疾病

疾病名称 别名
Splenic Tuberculosis

Tuberculosis, Splenic
Hypermethioninemia

Hepatic Methionine Adenosyltransferase Deficiency

Glycine N-Methyltransferase Deficiency

Met

S-Adenosylhomocysteine Hydrolase Deficiency

Deficiency Of Methionine Adenosyltransferase

Gnmt Deficiency

Mat Deficiency

Methionine Adenosyltransferase Deficiency

Methioninemia

Deficiency Of Acetyl-Coa Acetyltransferase
Purine-Pyrimidine Metabolic Disorder

Inborn Errors Of Purine-Pyrimidine Metabolism

Disorder Of Purine Or Pyrimidine Metabolism
Hypermethioninemia Due To Adenosine Kinase Deficiency

Adk Hypermethioninemia

Hypermethioninemia Encephalopathy Due To Adenosine Kinase Deficiency

Hypermethioninemia Encephalopathy Due To Adk Deficiency

Mrt8

Mental Retardation, Autosomal Recessive 8, Formerly

Mrt8, Formerly

HMAKD

Mental Retardation, Autosomal Recessive 8
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P2952 Adenylate / 否
HY-158820 Cosdosiran / 否
HY-158820A Cosdosiran sodium / 否
HY-E70364 IgdE protease / 否
HY-RS00383 ADK Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00384 Adk Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00385 Adk Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ADK RGD RGD:2046
Canis familiaris ADK VGNC VGNC:37659
Mus musculus ADK MGD MGI:87930
Macaca mulatta ADK VGNC VGNC:69698
Felis catus ADK VGNC VGNC:59644
Others ADK NCBI
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