CORT - cortistatin Gene

中文名称：皮质抑素

种属: Homo sapiens

同用名: SST2; CST-14; CST-17; CST-29

关于 CORT

功能概要

该基因编码一种结构类似于生长抑素的神经肽。它与所有已知的生长抑素受体结合，并与生长抑素具有许多药理学和功能特性，包括抑制神经元活动。然而，它也有许多不同于生长抑素的特性，例如诱导慢波睡眠，显然是通过拮抗乙酰胆碱对皮层的兴奋作用、减少运动活性和激活对生长抑素无反应的阳离子选择性电流。前原蛋白进一步加工成多种成熟产物。该基因与上游 APITD1 (诱导细胞凋亡，TAF9 样结构域 1) 基因之间存在通读转录本，如 GeneID：100526739 所示。[RefSeq 提供，2010 年 11 月]

This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]