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  3. Dnmt3b - DNA methyltransferase 3B Gene

Dnmt3b - DNA methyltransferase 3B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: MmuIIIB

基因 ID: 13436 | 基因类型: protein coding

关于 Dnmt3b

功能概要

This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]

Dnmt3b 基因产物(9)

mRNA Protein Name
NM_001003960.4 NP_001003960.2 DNA (cytosine-5)-methyltransferase 3B isoform 2
NM_001003961.4 NP_001003961.2 DNA (cytosine-5)-methyltransferase 3B isoform 1
NM_001003963.4 NP_001003963.2 DNA (cytosine-5)-methyltransferase 3B isoform 4
NM_001122997.2 NP_001116469.1 DNA (cytosine-5)-methyltransferase 3B isoform 5
NM_001271744.1 NP_001258673.1 DNA (cytosine-5)-methyltransferase 3B isoform 1
NM_001271745.1 NP_001258674.1 DNA (cytosine-5)-methyltransferase 3B isoform 2
NM_001271746.1 NP_001258675.1 DNA (cytosine-5)-methyltransferase 3B isoform 4
NM_001271747.1 NP_001258676.1 DNA (cytosine-5)-methyltransferase 3B isoform 3
NM_010068.5 NP_034198.3 DNA (cytosine-5)-methyltransferase 3B isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA (cytosine-5-)-methyltransferase activity IDA
IDA: 通过直接分析推断
9662389 MGI
enables DNA (cytosine-5-)-methyltransferase activity IGI
IGI: 通过遗传相互作用推断
17938196 MGI
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates IDA
IDA: 通过直接分析推断
27856912 MGI
enables DNA binding IDA
IDA: 通过直接分析推断
21378119 MGI
enables lncRNA binding IDA
IDA: 通过直接分析推断
25686699 MGI
enables methyltransferase activity IDA
IDA: 通过直接分析推断
11919202 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11934864 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA methylation-dependent heterochromatin formation IGI
IGI: 通过遗传相互作用推断
17938196 MGI
acts upstream of or within autosome genomic imprinting IMP
IMP: 通过突变表型推断
11934864 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: 通过直接分析推断
20548288 MGI
acts upstream of or within epigenetic programming of gene expression IGI
IGI: 通过遗传相互作用推断
10555141 MGI
involved in epigenetic regulation of gene expression IEP
IEP: 通过表达模式推断
18814855 MGI
acts upstream of or within gene silencing by piRNA-directed DNA methylation IDA
IDA: 通过直接分析推断
27856912 MGI
acts upstream of or within heterochromatin formation IMP
IMP: 通过突变表型推断
22516971 MGI
involved in negative regulation of gene expression, epigenetic IMP
IMP: 通过突变表型推断
18056424 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22133874 MGI
acts upstream of or within protein-containing complex localization IDA
IDA: 通过直接分析推断
16543361 MGI
acts upstream of or within retrotransposon silencing by heterochromatin formation IDA
IDA: 通过直接分析推断
27856912 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome, centromeric region IDA
IDA: 通过直接分析推断
15456878 MGI
located in heterochromatin IDA
IDA: 通过直接分析推断
11934864 MGI
located in nucleus IDA
IDA: 通过直接分析推断
16543361 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

DNA (cytosine-5)-methyltransferase 3B

DNA MTase MmuIIIB

DNA methyltransferase MmuIIIB

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13962 SGI-1027 99.77% 否
HY-101925 CM-272 98.70% 否
HY-103397 Nanaomycin A Inhibitor 98.18% 否
HY-124131 DS-437 Inhibitor 99.22% 否
HY-111544 EML741 Inhibitor / 否
HY-149389 PNMT-IN-1 Inhibitor / 否
HY-RS03912 DNMT3B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16772 Dnmt3b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23212 Dnmt3b Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dnmt3b NCBI NCBI:1789
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