TAAR1 - trace amine associated receptor 1 Gene

中文名称：微量胺相关受体 1

种属: Homo sapiens

同用名: TA1; TAR1; TRAR1

基因 ID: 134864 | 基因类型: protein coding

关于 TAAR1

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:132,643,312-132,659,182 (from NCBI)

This gene has 1 transcript (splice variant), 601 orthologues and 25 paralogues.

功能概要

该基因编码的蛋白质是由微量胺激活的 G 蛋白偶联受体。编码的蛋白质对多巴胺、血清素、肾上腺素或组胺反应很少或根本没有反应，但对 β-苯乙胺、对酪胺、章鱼胺和色胺反应良好。虽然主要在神经系统中发挥作用，但有证据表明该基因也参与血细胞和免疫功能。该基因被认为是无内含子的。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]

TAAR1 基因产物(1)

mRNA	Protein	Name
NM_138327.4	NP_612200.1	trace amine-associated receptor 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G protein-coupled receptor activity	IDA IDA: 通过直接分析推断	11723224	GOA
enables trace-amine receptor activity	IDA IDA: 通过直接分析推断	11459929	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	11723224	GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	31399635	GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	37935376	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	37935376	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in endomembrane system	IDA IDA: 通过直接分析推断	11723224	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TAAR1 蛋白结构

7tm_1

0
100
200
300
339 a.a.

蛋白主名

其他名称

trace amine-associated receptor 1

trace amine receptor 1

关联疾病

疾病名称

别名

Superficial Urinary Bladder Cancer

Superficial Urinary Bladder Carcinoma

Carcinoma Of Urinary Bladder, Superficial

Hypoparathyroidism-Deafness-Renal Disease Syndrome

Barakat Syndrome	Hypoparathyroidism, Deafness, Renal Disease Syndrome
Hdr Syndrome	Hypoparathyroidism, Sensorineural Deafness, And Renal Disease

Baastrup'S Syndrome

Kissing Spine	Baastrup Syndrome
Kissing Spine, Site Unspecified	Osteoarthrosis Interspinalis
Overriding Of Dorsal Spinous Processes	Localised Idiopathic Skeletal Hyperostosis
Baastrup Disease

Diamond-Blackfan Anemia 7

DBA7	Rpl11-Related Diamond-Blackfan Anemia
Anemia, Diamond-Blackfan, Type 7

Trichothiodystrophy 6, Nonphotosensitive

TTD6	Nonphotosensitive Trichothiodystrophy 6
Trichothiodystrophy 6, Non-Photosensitive

Joubert Syndrome 32

JBTS32

Greig Cephalopolysyndactyly Syndrome

GCPS	Polysyndactyly With Peculiar Skull Shape
Polysyndactyly With Peculiars Skull Shape	Greig Syndrome
Cephalopolysyndactyly Syndrome	Greig Cephalo-Poly-Syndactyly Syndrome
Cephalopolysyndactyly, Greig Syndrome	Aarskog Syndrome

Acrocallosal Syndrome

ACLS	Schinzel Acrocallosal Syndrome
Joubert Syndrome 12	Schinzel Syndrome 1
Acrocallosal Syndrome, Schinzel Type	Hallux Duplication, Postaxial Polydactyly, And Absence Of Corpus Callosum
Acs	Absence Of Corpus Callosum With Unusual Facial Appearance, Mental Deficiency, Duplication Of The Halluces And Polydactyly
Hallux Duplication Postaxial Polydactyly And Absence Of Corpus Callosum	JBTS12
Acrocallosal Syndrome

Pallister-Hall Syndrome

PHS	Hypothalamic Hamartomas
Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly	Hypothalamic Hamartoblastoma Syndrome
Hamartoma Of The Hypothalamus	Pallister Hall Syndrome
Hall-Pallister Syndrome	Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly
Hamartoma, Hypothalamic

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-176141	ZH8965	Agonist	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	TAAR1	VGNC	VGNC:83474
Mus musculus	TAAR1	MGD	MGI:2148258
Bos taurus	TAAR1	VGNC	VGNC:35553
Felis catus	TAAR1	VGNC	VGNC:65912
Rattus norvegicus	TAAR1	RGD	RGD:621621

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