Drd4 - dopamine receptor D4 Gene

中文名称：多巴胺受体 D4

种属: Mus musculus

同用名: D4R; Drd-4

关于 Drd4

功能概要

该基因编码的蛋白可启动多巴胺神经递质受体活性，通过 Gi/Go 耦合。参与昼夜节律的调节和突触后神经递质受体内化的调节。作用于多个过程的上游或内部，包括腺苷酸环化酶抑制多巴胺受体信号通路；对可卡因的行为反应；和抑制性突触后电位。在谷氨酸能突触中活跃。以多种结构表达，包括消化系统；中枢神经系统;淋巴系统腺体；外皮系统；和生殖系统。该基因的人类直系同源物与多种疾病有关，包括吉尔斯德拉图雷特综合征；反社会人格障碍；注意力缺陷多动障碍;品行障碍;和阅读障碍。与人类 DRD4（多巴胺受体 D4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in regulation of circadian rhythm and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within several processes, including adenylate cyclase-inhibiting Dopamine Receptor signaling pathway; behavioral response to cocaine; and inhibitory postsynaptic potential. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system gland; integumental system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Orthologous to human DRD4 (Dopamine Receptor D4). [provided by Alliance of Genome Resources, Apr 2022]