1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. UCSF924

UCSF924 

目录号: HY-125751
产品使用指南

UCSF924 是一种有效且特异性的多巴胺 D4 受体 (DRD4) 部分激动剂,EC50 值为 4.2 nM。UCSF924 具有高亲和力,对 DRD4 的 Ki 值为 3 nM,而对 D2,D3 或 F261V/ L328F D4 突变体没有可测的亲和力。对于 Gαi/o 信号传导,UCSF924 是抑制蛋白的 7.4 倍偏倚。

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UCSF924 Chemical Structure

UCSF924 Chemical Structure

CAS No. : 1434515-70-4

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Description

UCSF924 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC50 of 4.2 nM. UCSF924 has a high-affinity with a Ki value of 3 nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L328F D4 mutant. UCSF924 is a 7.4-fold bias toward arrestin over Gαi/o signaling, referenced to quinpirole[1].

IC50 & Target

Ki: 3 nM (dopamine D4 receptor)[1]

Molecular Weight

322.40

Formula

C₂₀H₂₂N₂O₂

CAS No.

1434515-70-4

SMILES

OC1=CC(CNCCCOC2=CC=CC=C2)=NC3=CC=C(C)C=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

UCSF924UCSF 924UCSF-924Dopamine ReceptorprobeInhibitorinhibitorinhibit

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产品名称:
UCSF924
目录号:
HY-125751
需求量: