1. Gene
  2. PACRG - parkin coregulated Gene

PACRG - parkin coregulated Gene


种属: Homo sapiens

同用名: GLUP; PACRG2.1; PARK2CRG; HAK005771

基因 ID: 135138 | 基因类型: protein coding


Cytogenetic location: 6q26 Genomic coordinates (GRCh38): 6:162,727,132-163,315,500 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 1 paralogue. Low expression observed in reference dataset.


该基因编码一种跨后生动物保守的蛋白质。在脊椎动物中,该基因与相邻的帕金基因呈头对头排列,后者与常染色体隐性幼年帕金森病有关。这些基因在各种组织中共同调节,它们共享一个双向启动子。这两个基因都与麻风病的易感性有关。 parkin 共调节基因蛋白与伴侣蛋白形成大分子复合物,包括热休克蛋白 70 和 90,以及伴侣蛋白成分。这种蛋白质也是帕金森病患者路易体的组成部分,它抑制未折叠的 Pael 受体诱导的神经元细胞死亡。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2008 年 7 月]

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PACRG 基因产物(3)

mRNA Protein Name
NM_001080378.2 NP_001073847.1 parkin coregulated gene protein isoform 2
NM_001080379.2 NP_001073848.1 parkin coregulated gene protein isoform 2
NM_152410.3 NP_689623.2 parkin coregulated gene protein isoform 1

PACRG 蛋白结构


ParcG: Parkin co-regulated protein (70 - 205)


ParcG: Parkin co-regulated protein (240 - 292)

  • 0
  • 100
  • 200
  • 296 a.a.
蛋白主名 其他名称

parkin coregulated gene protein

PARK2 co-regulated


疾病名称 别名
Parkinson Disease 2, Autosomal Recessive Juvenile

Young-Onset Parkinson Disease



Autosomal Recessive Juvenile Parkinson Disease 2


Parkinson Disease, Juvenile, Type 2

Parkinson'S Disease 2

Autosomal Recessive Juvenile Parkinson Disease

Early-Onset Parkinson Disease

Parkinson Disease 2

Parkinson Disease, Juvenile, Autosomal Recessive

Parkinsonism, Early-Onset, With Diurnal Fluctuation

Autosomal Recessive Juvenile Parkinson'S Disease 2


Juvenile Parkinsonism

Parkinson Disease Autosomal Recessive, Early Onset

Parkinsonism, Early Onset, With Diurnal Fluctuation


Autosomal Recessive Early-Onset Parkinson Disease Type 2

Chromosome 6-Linked Autosomal Recessive Parkinsonism

Early-Onset Parkinsonism With Diurnal Fluctuation

Parkinsonism Young Adult Onset

Parkinson Disease, Type 2

Parkinsonism, Juvenile

Parkin Type Of Early-Onset Parkinson Disease


Prkn Parkinson Disease



Idiopathic Parkinsonism

Primary Parkinsonism

Paralysis Agitans Syndrome

Parkinsonian Syndrome

Trembling Paralysis

Paralysis Agitans

Shaking Palsy

Shaking Paralysis

Leprosy 3


Leprosy, Susceptibility To, 3

Hansen'S Disease

Leprosy, Susceptibility To

Hansen Disease

Infection Due To Mycobacterium Leprae


Leprosy, Type 3

Anaesthesia Leprosy

Anaesthetic Leprosy

Maculoanaesthetic Leprosy

Macular Leprosy

Leprosy Unspecified

Dermatitis, Atopic, 3


Dermatitis, Atopic, Susceptibility To, 3

Atopic Dermatitis 3

Dermatitis, Atopic, With Asthma

Dermatitis, Atopic 3

Atopic Dermatitis With Asthma

Indeterminate Leprosy

Uncharacteristic Leprosy

Tuberculoid Leprosy

Smooth Leprosy

Type T Leprosy

Leprosy Tuberculoid

Leprosy, Tuberculoid


Hydrocephalus, Nonsyndromic, Autosomal Recessive

Hydrocephalus, X-Linked

Hydrocephalus Adverse Event

Hydrocephaly Nos

Paratyphoid Fever

Paratyphoid B Fever

Paratyphoid C Fever

Paratyphoid Fever A

Paratyphoid Fever B

Paratyphoid Fever C


Paratyphoid A

Paratyphoid A Fever

Paratyphoid B

Paratyphoid C

Infection Due To Salmonella Paratyphi

Lepromatous Leprosy

Leprosy, Lepromatous

Type L Leprosy

Leprosy Lepromatous

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease



Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease


Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Epilepsy, Myoclonic Juvenile

Juvenile Myoclonic Epilepsy

Janz Syndrome


Myoclonic Epilepsy, Juvenile, Susceptibility To, 1


Myoclonic Epilepsy, Juvenile

Petit Mal, Impulsive

Myoclonic Epilepsy, Juvenile 1

Myoclonic Epilepsy, Juvenile, 1

Adolescent Myoclonic Epilepsy

Juvenile Myoclonus Epilepsy

Juvenile Myoclonic Epilepsy 1


Petit Mal Impulsive

Susceptibility To Juvenile Myoclonic Epilepsy 1

Myoclonic Epilepsy Juvenile

Epilepsy, Myoclonic, Juvenile

Myoclonic Epilepsy Of Janz

Jme - [Juvenile Myoclonic Epilepsy]

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis


Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary


Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Macaca mulatta PACRG VGNC VGNC:75646
Bos taurus PACRG VGNC VGNC:55070
Mus musculus PACRG MGD MGI:1916560
Felis catus PACRG VGNC VGNC:102479
Rattus norvegicus PACRG RGD RGD:1561027